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Semaglutide
  • Synonyms: NN-9535
  • ATC: A10BJ06
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:4113.6 g/mol
  • CAS-RN:910463-68-2
  • InChI Key:DLSWIYLPEUIQAV-CCUURXOWSA-N
  • InChI:InChI=1S/C187H291N45O59/c1-​18-​105(10)​154(180(282)​208-​108(13)​159(261)​216-​133(86-​114-​89-​200-​119-​50-​40-​39-​49-​117(114)​119)​170(272)​218-​129(82-​102(4)​5)​171(273)​228-​152(103(6)​7)​178(280)​215-​121(53-​44-​72-​199-​186(192)​193)​162(264)​201-​91-​141(242)​209-​120(52-​43-​71-​198-​185(190)​191)​161(263)​204-​94-​151(257)​258)​230-​172(274)​131(83-​111-​45-​33-​31-​34-​46-​111)​219-​167(269)​126(64-​69-​149(253)​254)​214-​166(268)​122(51-​41-​42-​70-​195-​144(245)​98-​290-​79-​78-​289-​76-​74-​197-​145(246)​99-​291-​80-​77-​288-​75-​73-​196-​139(240)​66-​61-​127(183(285)​286)​211-​140(241)​54-​37-​29-​27-​25-​23-​21-​19-​20-​22-​24-​26-​28-​30-​38-​55-​146(247)​248)​212-​158(260)​107(12)​206-​157(259)​106(11)​207-​165(267)​125(60-​65-​138(189)​239)​210-​142(243)​92-​202-​163(265)​123(62-​67-​147(249)​250)​213-​168(270)​128(81-​101(2)​3)​217-​169(271)​130(85-​113-​56-​58-​116(238)​59-​57-​113)​220-​175(277)​135(95-​233)​223-​177(279)​137(97-​235)​224-​179(281)​153(104(8)​9)​229-​174(276)​134(88-​150(255)​256)​221-​176(278)​136(96-​234)​225-​182(284)​156(110(15)​237)​231-​173(275)​132(84-​112-​47-​35-​32-​36-​48-​112)​222-​181(283)​155(109(14)​236)​227-​143(244)​93-​203-​164(266)​124(63-​68-​148(251)​252)​226-​184(287)​187(16,​17)​232-​160(262)​118(188)​87-​115-​90-​194-​100-​205-​115/h31-​36,​39-​40,​45-​50,​56-​59,​89-​90,​100-​110,​118,​120-​137,​152-​156,​200,​233-​238H,​18-​30,​37-​38,​41-​44,​51-​55,​60-​88,​91-​99,​188H2,​1-​17H3,​(H2,​189,​239)​(H,​194,​205)​(H,​195,​245)​(H,​196,​240)​(H,​197,​246)​(H,​201,​264)​(H,​202,​265)​(H,​203,​266)​(H,​204,​263)​(H,​206,​259)​(H,​207,​267)​(H,​208,​282)​(H,​209,​242)​(H,​210,​243)​(H,​211,​241)​(H,​212,​260)​(H,​213,​270)​(H,​214,​268)​(H,​215,​280)​(H,​216,​261)​(H,​217,​271)​(H,​218,​272)​(H,​219,​269)​(H,​220,​277)​(H,​221,​278)​(H,​222,​283)​(H,​223,​279)​(H,​224,​281)​(H,​225,​284)​(H,​226,​287)​(H,​227,​244)​(H,​228,​273)​(H,​229,​276)​(H,​230,​274)​(H,​231,​275)​(H,​232,​262)​(H,​247,​248)​(H,​249,​250)​(H,​251,​252)​(H,​253,​254)​(H,​255,​256)​(H,​257,​258)​(H,​285,​286)​(H4,​190,​191,​198)​(H4,​192,​193,​199)/t105-,​106-,​107-,​108-,​109+,​110+,​118-,​120-,​121-,​122-,​123-,​124-,​125-,​126-,​127+,​128-,​129-,​130-,​131-,​132-,​133-,​134-,​135-,​136-,​137-,​152-,​153-,​154-,​155-,​156-​/m0/s1

Substance Classes

Synthesis Path

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
Lorem Lorem oral once daily formulation
EU Lorem Lorem
Lorem Lorem oral once daily formulation
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,seddiamvoluptua.Atveroeosetaccusametjustoduodoloresetearebum.Stetclitakasd

References

    • a) Lau, J. et al., J. Med. Chem., (2015) 58, 7370-7380.
    • US 9 999 999 (Novo Nordisk; 6.3.2012; appl. 17.9.2008; EP-prior. 18.3.2005).
    • US 9 999 999 (Novo Nordisk; 17.9.2013; appl. 5.3.2012; EP-prior. 18.3.2005).
    • b) US 9999 9999999 (Novetide; 1.3.2018; appl. 22.9.2015; GR-prior. 23.9.2014).
    • CN 999 999 999 (Hangzhou Adlai Nortye Pharma; 18.2.2015; appl. 24.10.2014).
    • Chinese Journal of Pharmaceuticals, (2018) 49 (6), 742.
    • c) WO 9999 999999 (Shenzhen Jymed Technol.; 22.2.2018; appl. 20.5.2017; CN-prior. 19.8.2016).

  • Injection devices:

    • US 9 999 999 (Novo Nordisk; 1.4.2014; appl. 25.9.2012; EP-prior. 21.10.2004).
    • US 9 999 999 (Novo Nordisk; 15.9.2015; appl. 1.8.2010; EP-prior. 24.10.2008).
    • US 9 999 999 (Novo Nordisk; 8.11.2016; appl. 30.1.2014; DK-prior. 5.1.2001).
    • US 9 999 999 (Novo Nordisk; 3.10.2017; appl. 21.11.2014; EP-prior. 27.7.2005).
    • EP 9 999 999 (Novetide; 27.9.2017; appl. 22.9.2015; GR-prior. 23.9.2014).

  • Oral dosing and compositions:

    • Twarog, C. et al., Pharmaceutics, (2019) 11, 78.
    • WO 9999 999999 (Hoffmann-LaRoche/Emisphere; 13.3.2008; appl. 30.8.2007; USA-prior. 7.9.2006).
    • US 9 999 999 (Novo Nordisk; 8.3.2016; appl. 16.12.2011; USA-prior. 20.12.2010).
    • US 99 999 999 (Novo Nordisk; 2.10.2018; appl. 9.2.2016; USA-prior. 20.12.2010).
    • US 99 999 999 (Novo Nordisk; 2.11.2017; appl. 17.7.2017; EP-prior. 2.5.2013).
    • US 9 999 999 (Novo Nordisk; 12.6.2018; appl. 19.6.2013; EP-prior. 20.6.2012).
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