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Amprenavir

  • Synonyms: KUX 478, UX 478, 141W94
  • ATC: J05AE05
  • Use: Lorem  Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:505.64 g/mol
  • CAS-RN:161814-49-9
  • InChI Key:YMARZQAQMVYCKC-OEMFJLHTSA-N
  • InChI:InChI=1S/C25H35N3O6S/c1-​18(2)​15-​28(35(31,​32)​22-​10-​8-​20(26)​9-​11-​22)​16-​24(29)​23(14-​19-​6-​4-​3-​5-​7-​19)​27-​25(30)​34-​21-​12-​13-​33-​17-​21/h3-​11,​18,​21,​23-​24,​29H,​12-​17,​26H2,​1-​2H3,​(H,​27,​30)/t21-,​23-,​24+/m0/s1

Substance Classes

Synthesis Path



























Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
251105-80-3 C20H27N3O5S N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)-4-nitrobenzenesulfonamide Benzenesulfonamide, N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)-4-nitro-
160232-11-1 C22H31ClN2O3 benzyl [(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl](2-methylpropyl)carbamate monohydrochloride Carbamic acid, [(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl](2-methylpropyl)-, phenylmethyl ester, monohydrochloride
501-53-1 C8H7ClO2 benzyl chloroformate Carbonochloridic acid, phenylmethyl ester
160232-10-0 C27H38N2O5 benzyl [(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](2-methylpropyl)carbamate Carbamic acid, [(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](2-methylpropyl)-, phenylmethyl ester
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem
F Lorem Lorem
GB Lorem Lorem
I Lorem Lorem
USA Lorem Lorem ,1999
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,

References

    • a WO 9 999 999 (Vertex Pharm.; appl. 7.9.1993; USA-prior. 8.9.1992).
    •  US 9 999 999 (Vertex; 17.12.1996; appl. 7.9.1993).
    • aa Brown, H.C. et al.: J. Am. Chem. Soc. (JACSAT) 108, 2049-2054 (1986).
    • b WO 9 999 999 (Vertex Pharm.; appl. 18.4.1996; USA-prior. 19.4.1995; 8.9.1992).
    •  US 9 999 999 (Vertex; 3.3.1998; appl. 19.4.1995).
    • c JP 99 999 999 (Kissei Pharm.; appl. 26.10.1995).
  • nanocrystalline formulations:

    • WO 9 999 999 (Nanosystems; appl. 9.7.1998; USA-prior. 9.7.1997).
  • stable crystal polymorphs:

    • WO 9 999 999 (Vertex Pharm.; appl. 16.6.1998; USA-prior. 16.6.1997).
  • novel crystal form V:

    • WO 9 999 999 (Glaxo; 17.12.1998; appl. 11.6.1998; USA-prior. 13.6.1997).
  • combination with AZT:

    • US 9 999 999 (Vertex; 8.7.1997; appl. 5.12.1995).
    • WO 9 999 999 (Vertex Pharm.; 12.6.1997; appl. 5.12.1996; USA-prior. 5.12.1995).
  • crystallization of amprenavir:

    • JP 99 999 999 (Kissei Pharm.; appl. 7.9.1995).
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