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Barnidipine

  • Synonyms: Mepirodipine hydrochloride
  • ATC: C08CA12
  • Use: Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:528.01 g/mol
  • CAS-RN:104757-53-1
  • InChI Key:XEMPUKIZUCIZEY-YSCHMLPRSA-N
  • InChI:InChI=1S/C27H29N3O6.ClH/c1-17-23(26(31)35-3)25(20-10-7-11-21(14-20)30(33)34)24(18(2)28-17)27(32)36-22-12-13-29(16-22)15-19-8-5-4-6-9-19;/h4-11,14,22,25,28H,12-13,15-16H2,1-3H3;1H/t22-,25-;/m0./s1

Derivatives

    free base

  • Formula: C27H29N3O6
  • MW:491.54 g/mol
  • CAS-RN:104713-75-9

    racemate

  • Formula: C27H29N3O6
  • MW:491.54 g/mol
  • CAS-RN:71863-55-3

Substance Classes

Synthesis Path







Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
101930-01-2 C15H19NO3 (3S)-1-benzyl-3-(acetoacetoxy)pyrrolidine Butanoic acid, 3-oxo-, 1-(phenylmethyl)-3-pyrrolidinyl ester, (S)-
100-46-9 C7H9N benzylamine Benzenemethanamine
101385-90-4 C11H15NO (3S)-1-benzyl-3-hydroxypyrrolidine 3-Pyrrolidinol, 1-(phenylmethyl)-, (3S)-
1694-31-1 C8H14O3 tert-butyl acetoacetate Butanoic acid, 3-oxo-, 1,1-dimethylethyl ester
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
I Lorem Lorem
J Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlabore

References

    • a DE 9 999 999 (Yamanouchi Pharm.; appl. 7.2.1979; J-prior. 14.2.1978).
    •  US 9 999 999 (Yamanouchi; 2.9.1980; J-prior. 14.2.1978).
    • b CN 99 999 999 (Faming Zhuanli Sheqing Gonhai S.; appl. 11.10.1985; J-prior. 24.1.1985).
  • alternative syntheses:

    • Hirose, Y.; Kariya, K.; Sasaki, I.; Kuronom Y; Achiwa, K.: Tetrahedron Lett. (TELEAY) 34 (37), 5915 (1993).
    • JP 9 999 999 (Mercian Corp.; J-prior. 26.3.1993).
    • JP 9 999 999 (Amano Pharma Co.; prior. 3.9.1993).
  • alternative synthesis of optically active 1-benzyl-3-hydroxypyrrolidine:

    • JP 9 999 999 (Koei Chemical Co.; appl. 29.3.1996).
  • X-ray structure and synthesis of all enantiomers:

    • Tamazawa, K et al.: J. Med. Chem. (JMCMAR) 29 (12), 2504 (1986).