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Boceprevir
  • Synonyms: SCH503034
  • ATC: J05AP03
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:519.7 g/mol
  • CAS-RN:394730-60-0
  • InChI Key:LHHCSNFAOIFYRV-DOVBMPENSA-N
  • InChI:InChI=1S/C27H45N5O5/c1-​25(2,​3)​20(30-​24(37)​31-​26(4,​5)​6)​23(36)​32-​13-​15-​17(27(15,​7)​8)​18(32)​22(35)​29-​16(19(33)​21(28)​34)​12-​14-​10-​9-​11-​14/h14-​18,​20H,​9-​13H2,​1-​8H3,​(H2,​28,​34)​(H,​29,​35)​(H2,​30,​31,​37)/t15-,​16?,​17-,​18-,​20+/m0/s1

Synthesis Path









Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
62965-35-9 C11H21NO4 Boc-tert-leucine L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-
672325-96-1 C9H15NO2 3,4-dimethylcyclopropyl-proline methyl ester 3-Azabicyclo[3.1.0]hexane-2-carboxylic acid, 6,6-dimethyl-, methyl ester, (1R,2S,5S)-rel-
C20H34N2O5 3-[2-(3-tert-butylureido)-3,3-dimethylbutyryl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid methyl ester
C13H23NO3 N-Boc-3,4-dimethylcyclopropane prolinol
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
EU Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsit

References

    • Prongay, A. J. et al., J. Med. Chem., (2007) 50, 2310-2318.
    • Njoroge, F. G. et al., Acc. Chem. Res., (2008) 41, 50-59.
    • a,c Venkatraman, S. et al., J. Med. Chem., (2006) 49, 6074-6086.
    • US 9 999 999 (Schering-Plough; 20.11.2003; appl. 19.7.2001).
    • US 9 999 999 (Schering-Plough; 11.1.2007; appl. 31.5.2006; USA-prior. 2.6.2005).
    • US 9 999 999 (Schering Corp.; 21.2.2012; appl. 31.5.2006; USA-prior. 2.6.2005).
    • US RE 99999 (Schering Corp.; 3.4.2012; appl. 22.4.2011; USA-prior. 21.7.2000).
    • ba Zhang, R. et al., J. Org. Chem., (1999) 64, 330-331.
    • Mamai, A. et al., J. Org. Chem., (2001) 66, 455-460.
    • bb Nair, L. G. et al., J. Org. Chem., (2010) 75, 1285-1288.
    • Liang, L. T. et al., JACS, (2012) 134(14), 6467-6472.

  • synthesis of labelled Boceprevir:

    • Ren, S. et al., J. Labelled Compounds and Radiopharmaceuticals, (2012) 55(3), 108-114.
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