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Bedaquiline
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Synonyms:
R-207910; TCM-207
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ATC:
J04AK05
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Use:
Lorem
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Chemical name:
Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
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Formula:
Lorem ipsum dolor sit amet,
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MW:555.52 g/mol
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CAS-RN:843663-66-1
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InChI Key:QUIJNHUBAXPXFS-XLJNKUFUSA-N
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InChI:InChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1
Derivatives
Fumarate
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Formula:
C32H31BrN2O2 • C4H4O4
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MW:671.59 g/mol
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CAS-RN:845533-86-0
Synthesis Path
Substances Referenced in Synthesis Path
| CAS-RN |
Formula |
Chemical Name |
CAS Index Name |
| 316146-27-7 |
C15H14BrNO |
3-phenylpropionyl-(4-bromo)anilid |
|
| 654655-68-2 |
C16H11BrClN |
3-benzyl-6-bromo-2-chloro-quinoline |
|
| 654655-69-3 |
C17H14BrNO |
3-benzyl-6-bromo-2-methoxy-quinoline |
|
| 10320-49-7 |
C15H17NO |
3-dimethylamino-1'-propionyl-naphthalene |
|
| Lorem |
Lorem |
Lorem |
Lorem |
Trade Names
| Country |
Trade Name |
Vendor |
Annotation |
| USA |
Lorem |
Lorem
|
|
| EU |
Lorem |
Lorem
|
|
(wfm = withdrawn from market)
References
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- Andries, K. et al., Science, (2005) 307, 223.
- US 9 999 999 (Janssen; 03.03.2009; USA-prior. 25.07.2002).
- EP 9 999 999 (Janssen; 07.04.2010; USA-prior. 25.07.2002).
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Process:
- US 9 999 999 (Janssen; 18.10.2011; EP-prior. 25.05.2005).
- US 9 999 999 (Janssen; 08.01.2013; EP-prior. 25.05.2005).
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Fumarate:
- US 9 999 999 (Janssen; 01.10.2013; EP-prior. 05.12.2006).
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Improved synthesis:
- Lubanyana, H. et al., ACS Omega, (2020) 5, 3607.
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Catalytic Asymmetric Synthesis:
- Saga, Y. et al., J. Am. Chem. Soc., (2010) 132, 7905.
