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Bedaquiline

  • Synonyms: R-207910; TCM-207
  • ATC: J04AK05
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:555.52 g/mol
  • CAS-RN:843663-66-1
  • InChI Key:QUIJNHUBAXPXFS-XLJNKUFUSA-N
  • InChI:InChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1

Derivatives

    Fumarate

  • Formula: C32H31BrN2O2 • C4H4O4
  • MW:671.59 g/mol
  • CAS-RN:845533-86-0

Substance Classes

Synthesis Path




Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
316146-27-7 C15H14BrNO 3-phenylpropionyl-(4-bromo)anilid
654655-68-2 C16H11BrClN 3-benzyl-6-bromo-2-chloro-quinoline
654655-69-3 C17H14BrNO 3-benzyl-6-bromo-2-methoxy-quinoline
10320-49-7 C15H17NO 3-dimethylamino-1'-propionyl-naphthalene
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
EU Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolor

References

    • Andries, K. et al., Science, (2005) 307, 223.
    • US 9 999 999 (Janssen; 03.03.2009; USA-prior. 25.07.2002).
    • EP 9 999 999 (Janssen; 07.04.2010; USA-prior. 25.07.2002).
  • Process:

    • US 9 999 999 (Janssen; 18.10.2011; EP-prior. 25.05.2005).
    • US 9 999 999 (Janssen; 08.01.2013; EP-prior. 25.05.2005).
  • Fumarate:

    • US 9 999 999 (Janssen; 01.10.2013; EP-prior. 05.12.2006).
  • Improved synthesis:

    • Lubanyana, H. et al., ACS Omega, (2020) 5, 3607.
  • Catalytic Asymmetric Synthesis:

    • Saga, Y. et al., J. Am. Chem. Soc., (2010) 132, 7905.