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Carfilzomib
  • Synonyms: PR-171; analog of Epoxomicin
  • ATC: L01XG02
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:719.9 g/mol
  • CAS-RN:868540-17-4
  • InChI Key:BLMPQMFVWMYDKT-NZTKNTHTSA-N
  • InChI:InChI=1S/C40H57N5O7/c1-​27(2)​22-​32(36(47)​40(5)​26-​52-​40)​42-​39(50)​34(24-​30-​14-​10-​7-​11-​15-​30)​44-​38(49)​33(23-​28(3)​4)​43-​37(48)​31(17-​16-​29-​12-​8-​6-​9-​13-​29)​41-​35(46)​25-​45-​18-​20-​51-​21-​19-​45/h6-​15,​27-​28,​31-​34H,​16-​26H2,​1-​5H3,​(H,​41,​46)​(H,​42,​50)​(H,​43,​48)​(H,​44,​49)/t31-,​32-,​33-,​34-,​40+/m0/s1

Synthesis Path



Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
13139-15-6 C11H21NO4 N-Boc leucine L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-
962-39-0 C17H21NO4 L-phenylalanin-benzylester L-Phenylalanine, phenylmethyl ester
C27H36N2O5 N-Boc-Leu-Phe-OBn
100564-78-1 C15H21NO4 Boc-L-homo-phenylalanine Benzenebutanoic acid, .alpha.-[[(1,1-dimethylethoxy)carbonyl]amino]-, (.alpha.S)-
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,

References

    • Groll, M. et al., J. Am. Chem. Soc., (2000) 122, 1237-1238.
    • Zhou, H. J. et al., J. Med. Chem. (2009) 52, 3028-3038.
    • a US 9999 9999999 (Proteolix; 3.11.2005; appl. 14.4.2005; USA-prior. 15.4.2004).
    • US 9999 9999999 (Proteolix; 9.2.2006; appl. 8.8.2005; USA-prior. 6.8.2004).
    • US 9999 9999999 (Onyx; 26.4.2011; appl. 22.12.2011; USA-prior. 15.4.2004).
    • US 9 999 999 (Proteolix; 19.6.2007; appl. 14.4.2005; USA-prior. 15.4.2004).
    • US 9 999 999 (Proteolix; 17.2.2009; appl. 11.7.2007; USA-prior. 15.4.2004).
    • US 9 999 999 (Onyx; 6.3.2012; appl. 14.4.2005; USA-prior. 15.4.2004).
    • US 9 999 999 (Onyx; 26.6.2012; appl. 22.12.2011; USA-prior. 15.4.2004).
    • b Sin, N. et al., Bioorg. Med. Chem. Lett., (1999) 9, 2283-2288.

  • composition for enzyme inhibition:

    • US 9999 9999999 (Proteolix; 15.6.2006; appl. 7.12.2005; USA-prior. 7.12.2004).
    • US 9 999 999 (Onyx; 15.6.2010; appl. 7.12.2011; USA-prior. 7.12.2004).
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