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Cabotegravir

  • Synonyms: GSK 1265744; GSK 744
  • ATC: J05AJ04
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:405.36 g/mol
  • CAS-RN:1051375-10-0
  • InChI Key:WCWSTNLSLKSJPK-LKFCYVNXSA-N
  • InChI:InChI=1S/C19H17F2N3O5/c1-​9-​8-​29-​14-​7-​23-​6-​12(16(25)​17(26)​15(23)​19(28)​24(9)​14)​18(27)​22-​5-​10-​2-​3-​11(20)​4-​13(10)​21/h2-​4,​6,​9,​14,​26H,​5,​7-​8H2,​1H3,​(H,​22,​27)/t9-,​14+/m0/s1

Derivatives

    Sodium salt

  • Formula: C19H16F2N3NaO5
  • MW:427.33 g/mol
  • CAS-RN:1051375-13-3

Substance Classes

Synthesis Path













Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
C24H20F2N2O6 Dolutegravir, intermediate XVII
2749-11-3 C3H9NO (S)-alanilol
1335210-23-5 C13H17NO8 1-(2,2,-dimethoxyethyl)-5-methoxy-6-(methoxy-carbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
1335210-24-6 C13H14N2O6 (3S,11aR)-3-methyl-6-(methyloxy)-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem suspended release
Lorem ipsum Lorem inj. combo with Rilpirine
Lorem Lorem oral tabs with Cabotegravir sodium
EU Lorem Lorem inj. combo with Rilpirine
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,seddiamvoluptua.Atveroeoset

References

    • Mills, A. et al., AIDS, (2022) 36(2), 195-203.
    • a) Johns, B.A. et al., J. Med. Chem., (2013) 56(3), 5901-16.
    • b+c) Wang, H. et al, Org. Lett., (2015) 17, 564-567.
    • a-c) Hughes, D.L. et al., Org. Process Res. Dev., (2019) 23, 716-729.
    • US 9 999 999 (Shionogi/VIIV Healthcare; 2.4.2013; appl. 18.1.2012; JP-prior. 28.4.2005).
    • US 99 999 999 (Shionogi/VIIV Healthcare; 23.2.2021; appl. 1.5.2009; JP-prior. 28.4.2005).
    • US 9 999 999 (VIIV Healthcare; 18.11.2014; appl. 22.3.2011; USA-prior. 23.3.2010).
    • d) WO 9999 999999 (LEK Pharmaceutical; 21.7.2016; appl. 15.1.2016; EP-prior. 16.1.2015).
  • Pharmaceutical compositions:

    • US 99 999 99 (VIIV Healthcare; 18.1.2022; appl. 13.10. 2016; USA-prior. 16.9.2010).
  • Crystalline forms of cabotegravir sodium:

    • US 99 999 999 (Sandoz AG; 22.6.2021; appl. 25.1.2018; EP-prior. 16.2.2017).
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