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Cabotegravir
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Synonyms:
GSK 1265744; GSK 744
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ATC:
J05AJ04
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Use:
Lorem
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Chemical name:
Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
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Formula:
Lorem ipsum dolor sit amet,
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MW:405.36 g/mol
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CAS-RN:1051375-10-0
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InChI Key:WCWSTNLSLKSJPK-LKFCYVNXSA-N
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InChI:InChI=1S/C19H17F2N3O5/c1-9-8-29-14-7-23-6-12(16(25)17(26)15(23)19(28)24(9)14)18(27)22-5-10-2-3-11(20)4-13(10)21/h2-4,6,9,14,26H,5,7-8H2,1H3,(H,22,27)/t9-,14+/m0/s1
Derivatives
Sodium salt
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Formula:
C19H16F2N3NaO5
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MW:427.33 g/mol
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CAS-RN:1051375-13-3
Substances Referenced in Synthesis Path
| CAS-RN |
Formula |
Chemical Name |
CAS Index Name |
|
C24H20F2N2O6 |
Dolutegravir, intermediate XVII |
|
| 2749-11-3 |
C3H9NO |
(S)-alanilol |
|
| 1335210-23-5 |
C13H17NO8 |
1-(2,2,-dimethoxyethyl)-5-methoxy-6-(methoxy-carbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid |
|
| 1335210-24-6 |
C13H14N2O6 |
(3S,11aR)-3-methyl-6-(methyloxy)-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid |
|
| Lorem |
Lorem |
Lorem |
Lorem |
| Lorem |
Lorem |
Lorem |
Lorem |
| Lorem |
Lorem |
Lorem |
Lorem |
Trade Names
| Country |
Trade Name |
Vendor |
Annotation |
| USA |
Lorem |
Lorem
|
suspended release |
| Lorem ipsum |
Lorem
|
inj. combo with Rilpirine |
| Lorem |
Lorem
|
oral tabs with Cabotegravir sodium |
| EU |
Lorem |
Lorem
|
inj. combo with Rilpirine |
(wfm = withdrawn from market)
Formulations
- Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,seddiamvoluptua.Atveroeoset
References
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- Mills, A. et al., AIDS, (2022) 36(2), 195-203.
- a) Johns, B.A. et al., J. Med. Chem., (2013) 56(3), 5901-16.
- US 9 999 999 (Shionogi/VIIV Healthcare; 2.4.2013; appl. 18.1.2012; JP-prior. 28.4.2005).
- US 99 999 999 (Shionogi/VIIV Healthcare; 23.2.2021; appl. 1.5.2009; JP-prior. 28.4.2005).
- b+c) Wang, H. et al, Org. Lett., (2015) 17, 564-567.
- US 9 999 999 (VIIV Healthcare; 18.11.2014; appl. 22.3.2011; USA-prior. 23.3.2010).
- a-c) Hughes, D.L. et al., Org. Process Res. Dev., (2019) 23, 716-729.
- d) WO 9999 999999 (LEK Pharmaceutical; 21.7.2016; appl. 15.1.2016; EP-prior. 16.1.2015).
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Pharmaceutical compositions:
- US 99 999 99 (VIIV Healthcare; 18.1.2022; appl. 13.10. 2016; USA-prior. 16.9.2010).
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Crystalline forms of cabotegravir sodium:
- US 99 999 999 (Sandoz AG; 22.6.2021; appl. 25.1.2018; EP-prior. 16.2.2017).
