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Desoxycortone acetate

  • Synonyms: Deoxycorticosterone acetate, Deoxycortone acetate
  • ATC: H02AA03
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:372.51 g/mol
  • CAS-RN:56-47-3
  • InChI Key:VPGRYOFKCNULNK-ACXQXYJUSA-N
  • InChI:InChI=1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
  • EINECS:200-275-9

Derivatives

    desoxycortone

  • Formula: C21H30O3
  • MW:330.47 g/mol
  • CAS-RN:64-85-7
  • EINECS:200-596-4
  • LD50: 1 g/kg (M, route unreported)

Substance Classes

Synthesis Path

















Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
566-78-9 C23H34O4 (3β)-21-(acetyloxy)-3-hydroxypregn-5-en-20-one Pregn-5-en-20-one, 21-(acetyloxy)-3-hydroxy-, (3β)-
1162-53-4 C21H30O2 16-dehydropregnenolone Pregna-5,16-dien-20-one, 3-hydroxy-, (3β)-
95-92-1 C6H10O4 diethyl oxalate Ethanedioic acid, diethyl ester
C25H35NaO5 (3β)-3,23-dihydroxy-20-oxo-21-norchola-5,22-dien-24-oic acid ethyl ester sodium salt
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Lorem Lorem Lorem Lorem
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Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem as phenylpropionate-comb. wfm
F Lorem Lorem
GB Lorem ipsum dolor Lorem as pivalate wfm
I Lorem Lorem wfm
Lorem Lorem wfm
Lorem Lorem comb. wfm
USA Lorem ipsum Lorem wfm
Lorem Lorem wfm
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolor

References

    • a Sondheimer, F. et al.: J. Am. Chem. Soc. (JACSAT) 79, 5034 (1957).
  • synthesis of I:

    • Wall, M.E.: J. Am. Chem. Soc. (JACSAT) 77, 5665 (1955).
    • b Ringold, H.J.; Stork, G.: J. Am. Chem. Soc. (JACSAT) 80, 250 (1958).
    • c Ruschig, H.: Angew. Chem. (ANCEAD) 60, 247 (1948).
    •  Ruschig, H.: Chem. Ber. (CHBEAM) 88, 878 (1955).
  • alternative syntheses:

    • Serini, A. et al.: Ber. Dtsch. Chem. Ges. (BDCGAS) 72, 391 (1939).
    • Wilds, A.L.; Shunk, C.H.: J. Am. Chem. Soc. (JACSAT) 70, 2427 (1948).
    • DE 999 999 (Hoechst; appl. 1937).
    • DE 999 999 (Schering AG; appl. 1938).
    • US 9 999 999 (Roche-Organon; 1943, CH-prior. 1937).
    • US 9 999 999 (Schering Corp.; 1946, D-prior. 1939).
    • US 9 999 999 (W. C. Ross; 1949; GB-prior. 1945).
  • review:

    • Ullmanns Encykl. Tech. Chem., 4. Aufl., Vol. 13, 52.
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