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Darunavir

  • Synonyms: TMC-114, UIC-94017
  • ATC: J05AE10
  • Use: Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:547.67 g/mol
  • CAS-RN:206361-99-1
  • InChI Key:CJBJHOAVZSMMDJ-HEXNFIEUSA-N
  • InChI:InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1

Substance Classes

Synthesis Path




















Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
7535-56-0 C20H22N2O6 Boc-l-phenylalanine 4-nitrophenyl ester
110-63-4 C4H10O2 1,4-butanediol 1,4-Butanediol
18162-48-6 C6H15ClSi tert-butyldimethylsilyl chloride Silane, chloro(1,1-dimethylethyl)dimethyl-
102191-92-4 C8H18OSi (tert-butyldimethylsilyloxy)acetaldehyde
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem ,2007
I Lorem Lorem ,2007
USA Lorem Lorem ,2006
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,sed

References

    • Ghosh, A. K. et al.: J. Org. Chem. (JOCEAH) 69, 23, 7822 (2004).
    • Surleraux, D. L. N. G. et al.: J. Med. Chem. (JMCMAR) 48, 1813 (2005).
    • Gosh, A. K. et al.: J. Med. Chem. (JMCMAR) 49, 5252 (2006).
    • EP 99 999 999 (Tibotec; 14.7.2005; EP-prior. 23.12.2003).
  • preparation of V:

    • b Yu, R. H. et al.: Org. Process Res. Dev. (OPRDFK) 11, 972 (2007).
    •  Kesteleyn, B. R. R. et al.: Org. Lett. (ORLEF7) 7, 5912 (2005).
    •  Ghosh, A. K.; Li, J.; Perali, R. S.: Synthesis (SYNTBF) 18, 3015 (2006).
    •  Ghosh, A. K. et al.: Tetrahedron Lett. (TELEAY) 36, 4, 505 (1995).
    • a WO 9 999 999 999 (DSM IP Asseto; 27.3.2008; EP-prior. 19.9.2006).
    •  EP 9 999 999 (GILEAD Sciences; 11.8.2007; USA-prior. 29.3.2006).
    •  US 9 999 999 (Sumitomo Chemical Comp.; 23.12.2008; J-prior. 22.7.2002).
    •  US 9 999 999 (The Board of Trustees of the University of Illinois; 19.7.2005; USA-prior. 9.10.2002).
    •  US 9 999 999 (SmithKline Beecham; USA-prior. 20.9.2001; 5.12.2006).