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Edoxaban

  • Synonyms: DU-176b
  • ATC: -
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:548.1 g/mol
  • CAS-RN:912273-65-5 (480449-70-5)
  • InChI Key:HGVDHZBSSITLCT-JLJPHGGASA-N
  • InChI:InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15-,17+/m0/s1

Derivatives

    hydrochloride

  • Formula: C24H30ClN7O4S • HCl
  • MW:584.6 g/mol
  • CAS-RN:480448-29-1

    tosylate

  • Formula: C24H30ClN7O4S • C7H8O3S
  • MW:738.3 g/mol
  • CAS-RN:480449-71-6

    tosylate hydrate

  • Formula: C24H30ClN7O4S • C7H8O3S • H2O
  • MW:756.3 g/mol
  • CAS-RN:1229194-11-9

Synthesis Path



















Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
4771-80-6 C7H10O2 3-cyclohexene-1-carboxylic acid
365997-31-5 C9H14O3 ethyl (1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylate
365997-26-8 C14H25NO5 ethyl (1S,3R,4R)-3-[(t-butoxycarbonyl)amino]-4-hydroxycyclohexanecarboxylate
480449-83-0 C14H25N4O5 ethyl (1S,3R,4R)-4-azido-3-[(t-butoxycarbonyl)amino]-cyclohexanecarboxylate
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
J Lorem Lorem
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscing

References

    • a Nagata, T. et al., Bioorg. Med. Chem., (2009) 17, 1193.
    • b,c Yoshikawa, K. et al., Bioorg. Med. Chem., (2009) 17, 8206.
    • Yoshikawa, K. et al., Bioorg. Med. Chem., (2009) 17, 8221.
    • f Haginoya, N. et al., J. Med. Chem., (2004) 47, 5167.
    • WO 9 999 999 (Daiichi Seiyaku; 11.10.2001; appl. 5.4.2001; JP-prior. 5.4.2000).
    • US 9999 9999999 (Daiichi Pharms.; 10.9.2009; appl. 13.5.2009; JP-prior. 5.4.2000).
    • WO 9999 999999 (Daiichi Seiyaku; 15.7.2004; appl. 25.12.2003; JP-prior. 25.12.2002).
    • US 9999 9999999 (Daiichi Pharms.; 9.11.2006; appl. 25.12.2003; JP-prior. 25.12.2002).
    • da EP 9 999 999 (Daiichi Sankyo; 28.5.2008; appl. 15.9.2006; JP-prior. 16.9.2005).
    • db US 9999 9999999 (Daiichi Sankyo; 9.2.2012; appl. 13.9.2011; JP-prior. 13.3.2009).
    • e US 9999 9999999 (Daiichi Sankyo; 16.2.2012; appl. 9.9.2011; JP-prior. 10.3.2009).
    • WO 9999 999999 (Daiichi Sankyo; 30.5.2014; appl. 22.11.2013; IN-prior. 23.11.2012).