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Ertugliflozin
  • Synonyms: PF-04971729; MK-8835
  • ATC: A10BK04
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:436.89 g/mol
  • CAS-RN:1210344-57-2
  • InChI Key:MCIACXAZCBVDEE-CUUWFGFTSA-N
  • InChI:InChI=1S/C22H25ClO7/c1-​2-​28-​16-​6-​3-​13(4-​7-​16)​9-​14-​10-​15(5-​8-​17(14)​23)​22-​20(27)​18(25)​19(26)​21(11-​24,​30-​22)​12-​29-​22/h3-​8,​10,​18-​20,​24-​27H,​2,​9,​11-​12H2,​1H3/t18-,​19-,​20+,​21-,​22-​/m0/s1

Substance Classes

Synthesis Path



Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
C6H10O6 D-Gluconolactone
2183708-20-3 C18H42O6Si4 TMS-D-gluconolactone
461432-23-5 C15H14BrClO 4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene
C22H27ClO7 (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-hydroxymethyl-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
Lorem Lorem comb. w/Sitagliptin
Lorem Lorem comb. w/Metformin
EU Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinvidunt

References

    • Mascitti, V. et al., J. Med. Chem., (2011) 54, 2952-2960.
    • Berhardson, D. et al., OPRD, (2014) 18, 57-65.
    • Bowles, P. et al., OPRD, (2014) 18, 66-81.
    • US appln. 9999 9999999 A1; (Pfizer; publ. 04.03.2010; USA-prior. 28.08.2008; 21.07.2009; 24.08.2009).
    • US 9 999 999 (Pfizer; 20.12.2011; USA-prior. 28.08.2008; 21.07.2009; 24.08.2009).
    • US 9 999 999 (Pfizer; 11.03.2014; USA-prior. 02.11.2009; 12.08.2010; 21.10.2010).
    • US 9 999 999 (Pfizer; 12.04.2016; USA-prior. 02.11.2009; 12.08.2010; 21.10.2010; 12.03.2013; 07.11.2014).

  • Co-crystals with L-Pyroglutamic acid:

    • US 9 999 999 (MSD; 21.02.2017; USA-prior. 14.03.2013; 07.10.2013; 05.12.2013; 10.03.2014).

  • Combination with Sitagliptin:

    • US 9 999 999 (Pfizer; 13.09.2016; USA-prior. 02.11.2009; 12.08.2010; 21.10.2010; 12.03.2013; 07.11.2014).

  • Combination with Metformin:

    • US 9 999 999 (Pfizer; 13.09.2016; USA-prior. 02.11.2009; 12.08.2010; 21.10.2010; 12.03.2013; 07.11.2014).

  • Review:

    • Aguillón, A.R. et al., Synthetic strategies toward SGLT2 inhibitors, OPRD, (2018) 22, 467-488.
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