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Elexacaftor

  • Synonyms: VX-445; WHO 11180
  • ATC: R07AX32
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:597.7 g/mol
  • CAS-RN:2216712-66-0
  • InChI Key:MVRHVFSOIWFBTE-INIZCTEOSA-N
  • InChI:InChI=1S/C26H34F3N7O4S/c1-16-12-25(5,6)35(13-16)22-18(23(37)33-41(38,39)19-14-34(7)31-17(19)2)8-9-20(30-22)36-11-10-21(32-36)40-15-24(3,4)26(27,28)29/h8-11,14,16H,12-13,15H2,1-7H3,(H,33,37)/t16-/m0/s1

Substance Classes

Enzymes

Synthesis Path






















Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
34846-90-7 C5H8O3 Methyl (E)-3-methoxy-prop-2-enoate
2088458-39-1 C8H12N2O3 tert. butyl 3-oxo-2,3-dihydro-1H-pyrazole-1-carboxylate
1895296-01-1 C5H9F3O 3,3,3-trifluoro-2,2-dimethyl-1-propanol
229861-14-5 C12H19F3N2O3 tert. butyl 3-(3,3,3-trifluoro-2,2-dimethyl-propoxy)-pyrazole-1-carboxylate
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
EU Lorem Lorem
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,seddiamvoluptua.

References

    • Hughes, D.L., Org. Process Res. Dev., (2019) 21, 2302-2322.
    • a) WO 9999 999999 (Vertex Pharmaceuticals; 14.6.2018; appl. 8.12.2017; USA-prior. 9.12.2016).
    • WO 9999 999999 (Vertex Pharmaceuticals; 24.1.2019; appl. 17.7.2018; USA-prior. 17.7.2017).
    • US 99 999 999 (Vertex Pharmaceuticals; 6.10.2020; appl. 8.12.2017; USA-prior. 9.12.2016).
    • b) WO 9999 999999 (Vertex Pharmaceuticals; 7.2.2019; appl. 2.8.2018; USA-prior. 2.8.2017).
    • WO 9999 999999 (Vertex Pharmaceuticals; 13.6.2019; appl. 7.12.2018; USA-prior. 8.12.2017).
  • Pharmaceutical compositions and administrations:

    • WO 9999 999999 (Vertex Pharmaceuticals; 12.65.2020; appl. 31.8.2016; USA-prior. 13.8.2008).