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Flumetasone

  • Synonyms: Flumethasone
  • ATC: D07AB03; D07BB01; D07CB05; D07XB01; S02CA02
  • Use: Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:410.46 g/mol
  • CAS-RN:2135-17-3
  • InChI Key:WXURHACBFYSXBI-GQKYHHCASA-N
  • InChI:InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
  • EINECS:218-370-9

Derivatives

    pivalate

  • Formula: C27H36F2O6
  • MW:494.58 g/mol
  • CAS-RN:2002-29-1
  • EINECS:217-901-1
  • LD50: >5 g/kg (M, p.o.);
    >2 g/kg (R, p.o.)

Substance Classes

Enzymes

Synthesis Path



















Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
108-24-7 C4H6O3 acetic anhydride Acetic acid, anhydride
2118-11-8 C24H36O4 3β-acetoxy-5α,6α-epoxy-16α-methylpregnan-20-one Pregnan-20-one, 3-(acetyloxy)-5,6-epoxy-16-methyl-, (3β,5α,6α,16α)-
1524-93-2 C24H33FO6 21-acetoxy-6α-fluoro-11β,17-dihydroxy-16α-methylpregn-4-ene-3,20-dione Pregn-4-ene-3,20-dione, 21-(acetyloxy)-6-fluoro-11,17-dihydroxy-16-methyl-, (6α,11β,16α)-
3821-70-3 C24H33FO5 21-acetoxy-6β-fluoro-17-hydroxy-16α-methylpregn-4-ene-3,20-dione Pregn-4-ene-3,20-dione, 21-(acetyloxy)-6-fluoro-17-hydroxy-16-methyl-, (6β,16α)-
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
F Lorem Lorem
Lorem Lorem
Lorem Lorem
GB Lorem Lorem
I Lorem Lorem wfm
Lorem Lorem comb. wfm
Lorem Lorem wfm
Lorem Lorem comb. wfm
J Lorem Lorem Lorem
USA Lorem Lorem wfm
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtempor

References

    •  Djerassi, C. et al.: J. Am. Chem. Soc. (JACSAT) 81, 3156 (1959); 82, 2318 (1961).
    • a US 9 999 999 (Syntex; 1954; appl. 1951).
    • b FR 9 999 999 (Ciba; appl. 8.10.1963; CH-prior. 12.10.1962).
  • synthesis of 21-(2,2-dimethylpropionyloxy)-3,20-dioxo-6α-fluoro-17-hydroxy-16α-methyl-1,4,9(11)-pregnatriene:

    • US 9 999 999 (Upjohn; 19.1.1971; prior. 18.3.1959).
  • alternative syntheses:

    • Schneider, P. et al.: J. Am. Chem. Soc. (JACSAT) 81, 3167 (1959).
    • US 9 999 999 (Upjohn; 19.1.1971; appl. 22.1.1962; prior. 18.3.1959).
    • GB 999 999 (Upjohn; appl. 27.7.1959; USA-prior. 14.8.1958).
    • US 9 999 999 (Upjohn; 9.8.1977; appl. 17.11.1975).