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Fostemsavir

  • Synonyms: BMS-663068; GSK3684934; prodrug of Temsavir
  • ATC: J05AX29
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:583.5 g/mol
  • CAS-RN:864953-29-7
  • InChI Key:SWMDAPWAQQTBOG-UHFFFAOYSA-N
  • InChI:InChI=1S/C25H26N7O8P/c1-16-27-14-32(28-16)23-21-20(19(39-2)12-26-23)18(13-31(21)15-40-41(36,37)38)22(33)25(35)30-10-8-29(9-11-30)24(34)17-6-4-3-5-7-17/h3-7,12-14H,8-11,15H2,1-2H3,(H2,36,37,38)

Derivatives

    Tromethamine salt

  • Formula: C29H37N8O11P
  • MW:704.6 g/mol
  • CAS-RN:864953-39-9

Substance Classes

Synthesis Path













Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
1068-57-1 C2H6N2O acethydrazide
62-55-5 C2H5NS thioacetamide
7170-01-6 C3H5N3 3-methyl-1,2,4-triazole
446284-32-8 C8H7ClN2O 7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridine
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
EU Lorem Lorem
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,

References

    • Lai, Y.-T. et al., Nature Communications, (2019) 10 (1), 47.
    • Kozal, M. et al., N. Engl. J. Med., (2020), 382 (13), 1232-1243.
    • Meanwell, N. A. et al., J. Med. Chem., (2018) 61, 62-80.
    • Chen, K. et al., J. Org. Chem., (2014) 79, 8757-8767.
    • Fox, R. J. et al., Org. Process Res. Dev., (2017) 21, 1095-1109.
    • Chen, K. et al., Org. Process Res. Dev., (2017) 21, 1110-1121.
    • Bentner, G. L. et al., Org. Process Res. Dev., (2017) 21, 1122-1130.
    • Bultman, M. S. et al., Org. Process Res. Dev., (2017) 21, 1131-1136.
    • Gonzalez-Bobes, F. et al., OPRD, (2017) 21, 1137-1144.
    • Zheng, B. et al., OPRD, (2017) 21, 1145-1155.
    • Gallagher, W. et al., OPRD, (2017) 21, 1156-1165.
    • Fox, R. et al., OPRD, (2017) 21, 1166-1173.
    • La Cruz, T. E. et al., OPRD, (2017) 21, 1174-1185.
    • a) US 9 999 999 (Bristol-Myers-Squibb; 29.6.2010; appl. 25.2.2005; USA-prior. 10.12.2004).
    • US 9 999 999 (Bristol-Myers-Squibb; 1.5.2012; appl. 26.4.2010; USA-prior. 10.12.2004).
    • b) US 9 999 999 (Bristol-Myers-Squibb; 11.6.2013; appl. 26.3.2012; USA-prior. 10.12.2010).
  • Fostemsavir for use in heavily treatment - experienced HIV-1 infected individuals:

    • EP 9 999 999 (Bristol-Myers-Squibb; 12.12.2018; USA-prior. 4.2.2016).