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Granisetron

  • Synonyms: BRL-43694
  • ATC: A04AA02
  • Use: Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:312.42 g/mol
  • CAS-RN:109889-09-0
  • InChI Key:MFWNKCLOYSRHCJ-BTTYYORXSA-N
  • InChI:InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13+,14-

Derivatives

    monohydrochloride

  • Formula: C18H24N4O • HCl
  • MW:348.88 g/mol
  • CAS-RN:107007-99-8
  • LD50: 17 mg/kg (M, i.v.); 350 mg/kg (M, p.o.);
    14 mg/kg (R, i.v.); 350 mg/kg (R, p.o.)

Substance Classes

Synthesis Path






Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
4498-67-3 C8H6N2O2 indazole-3-carboxylic acid 1H-Indazole-3-carboxylic acid
76272-56-5 C9H18N2 endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine 9-Azabicyclo[3.3.1]nonan-3-amine, 9-methyl-, endo-
106649-02-9 C9H7ClN2O 1-methylindazole-3-carbonyl chloride 1H-Indazole-3-carbonyl chloride, 1-methyl-
50890-83-0 C9H8N2O2 1-methylindazole-3-carboxylic acid 1H-Indazole-3-carboxylic acid, 1-methyl-
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem
Lorem ipsum
F Lorem Lorem
GB Lorem Lorem
I Lorem Lorem
J Lorem Lorem
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreet

References

    • Bermudez, J. et al.: Bioorg. Med. Chem. Lett. (BMCLE8) 4 (20), 2376 (1994).
    • US 9 999 999 (Beecham; 12.12.1989; GB-prior. 27.4.1985, 21.10.1985).
    • EP 999 999 (Beecham; appl. 21.4.1986; GB-prior. 27.4.1985, 21.10.1985).
  • alternative synthesis:

    • WO 9 999 999 (SmithKline Beecham; appl. 11.2.1992; GB-prior. 13.2.1996).
  • synthesis of 1-methylindazole-3-carboxylic acid:

    • Bermudez, J. et al.: J. Med. Chem. (JMCMAR) 33, 1924 (1990).
    • EP 999 999 (Beecham; appl. 19.12.1988; GB-prior. 22.12.1987).
  • synthesis of granataneamine:

    • Jones, G.; Stanger, J.: J. Chem. Soc. C (JSOOAX) 1969, 901.
  • medical use for treatment of CNS and cognitive disorders:

    • EP 999 999 (Beecham; appl. 7.10.1986; GB-prior. 21.10.1985).
    • EP 999 999 (Glaxo; appl. 16.12.1987; GB-prior. 17.12.1986, 25.3.1987).
  • medical use for treatment of withdrawal syndrome:

    • EP 999 999 (Glaxo; appl. 20.11.1987; GB-prior. 21.11.1986, 25.3.1987).
    • EP 999 999 (Glaxo; appl. 20.11.1987; GB-prior. 21.11.1986, 25.3.1987).
  • medical use for treatment of visceral pain:

    • EP 999 999 (Beecham; appl. 18.1.1988; GB-prior. 19.1.1987).
    • US 9 999 999 (Beecham; 4.7.1989; appl. 19.1.1988; GB-prior. 19.1.1987).
  • medical use for treatment of cough and bronchoconstriction:

    • EP 999 999 (Beecham; appl. 14.11.1988; GB-prior. 14.11.1987).
  • medical use for treatment of myocardial instability:

    • WO 9 999 999 (Beecham; appl. 20.12.1990; GB-prior. 21.12.1989).