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Hydrocortisone
  • ATC: A01AC03; A07EA02; C05AA01; D07AA02; D07XA01; H02AB09; S01BA02; S01CB03; S02BA01
  • Use: Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:362.47 g/mol
  • CAS-RN:50-23-7
  • InChI Key:JYGXADMDTFJGBT-VWUMJDOOSA-N
  • InChI:InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
  • EINECS:200-020-1
  • LD50: >500 mg/kg (M, s.c.);
    150 mg/kg (R, i.p.); 449 mg/kg (R, s.c.)

Substance Classes

Enzymes

Synthesis Path


























Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
108-24-7 C4H6O3 acetic anhydride Acetic acid, anhydride
50-04-4 C23H30O6 21-O-acetylcortisone Pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-
31085-34-4 C23H32O4 (11β,17Z)-21-(acetyloxy)-11-hydroxypregna-4,17(20)-dien-3-one Pregna-4,17(20)-dien-3-one, 21-(acetyloxy)-11-hydroxy-, (11β,17Z)-
96671-22-6 C26H36O7 (3β)-17,21-bis(acetyloxy)-3-(formyloxy)pregn-5-en-20-one Pregn-5-en-20-one, 17,21-bis(acetyloxy)-3-(formyloxy)-, (3β)-
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem
Lorem ipsum Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem ipsum Lorem
Lorem Lorem
Lorem Lorem
Lorem ipsum Lorem
Lorem ipsum Lorem
Lorem ipsum dolor sit amet,
F Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
GB Lorem Lorem
Lorem Lorem
Lorem Lorem
I Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem ipsum Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem ipsum dolor
J Lorem Lorem
Lorem ipsum Lorem comb. with crotamiton
Lorem Lorem comb. with fradiomycin
Lorem Lorem comb. with sodium succinate
Lorem Lorem comb. with oxytetracycline
USA Lorem ipsum Lorem
Lorem Lorem
Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinvidunt

References

    • a US 9 999 999 (Upjohn; 1953; appl. 1950).
    •  US 9 999 999 (Pfizer; 1953; appl. 1952).
    •  US 9 999 999 (Upjohn; 9999 appl. 1954).

  • synthesis of cortexolon:

    • Julian, P.L.: J. Am. Chem. Soc. (JACSAT) 72, 5145 (1950).
    • Sondheimer, F. et al.: J. Am. Chem. Soc. (JACSAT) 78, 816 (1956).
    • The Merck Index, 2891 (Rahway 1976).
    • b Oliveto, E. et al.: J. Am. Chem. Soc. (JACSAT) 78, 1736 (1956).
    • c US 9 999 999 (American Cyanamid; 1954; appl. 1951).

  • synthesis of starting material:

    • d Hogg, J.A. et al.: J. Am. Chem. Soc. (JACSAT) 77, 4436 (1955).
    • US 9 999 999 (American Cyanamid; 1952; appl. 1951).
    • US 9 999 999 (American Cyanamid; 1955; appl. 1953).
    •  US 9 999 999 (Upjohn; 1956; appl. 1954).

  • alternative syntheses:

    • US 9 999 999 (Merck & Co.; 1951; appl. 1947).
    • GB 999 999 (Pfizer; appl. 1956; USA-prior. 1955).
    • US 9 999 999 (Upjohn; 9.8.1977; appl. 17.11.1975).
    • DOS 9 999 999 (Schering AG; appl. 25.1.1978).
    • DOS 9 999 999 (Schering AG; appl. 25.1.1978).

  • review:

    • Fieser, L.F.; Fieser, M.: Steroide, 710, 737 (Weinheim 1961).
    • Ullmanns Encykl. Tech. Chem., 4. Aufl., Vol. 13, 52.

  • pharmaceutical formulation:

    • DOS 9 999 999 (Dermal; appl. 18.2.1976; GB-prior. 19.2.1975).
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