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Lemborexant
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Synonyms:
E-2006
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ATC:
N05CM21
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Use:
Lorem
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Chemical name:
Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
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Formula:
Lorem ipsum dolor sit amet,
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MW:410.43 g/mol
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CAS-RN:1369764-02-2
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InChI Key:MUGXRYIUWFITCP-PGRDOPGGSA-N
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InChI:InChI=1S/C22H20F2N4O2/c1-13-19(11-25-14(2)27-13)30-12-22(15-4-3-5-16(23)8-15)9-18(22)21(29)28-20-7-6-17(24)10-26-20/h3-8,10-11,18H,9,12H2,1-2H3,(H,26,28,29)/t18-,22+/m0/s1
Synthesis Path
Substances Referenced in Synthesis Path
| CAS-RN |
Formula |
Chemical Name |
CAS Index Name |
| 501-00-8 |
C8H6FN |
3-fluorophenyl-acetonitrile |
|
| 51594-55-9 |
C3H5ClO |
R-Epichlorhydrin |
|
|
C11H10FNO |
1(S)-(3-fluorophenyl)-2(R)-(hydroxymethyl)cyclopropane-carbonitrile |
|
| 528587-70-4 |
C11H9FO2 |
(1S,5R)-1-(3-fluorophenyl)-3-oxabicyclo[3.1.0]hexan-2-one |
|
| Lorem |
Lorem |
Lorem |
Lorem |
| Lorem |
Lorem |
Lorem |
Lorem |
| Lorem |
Lorem |
Lorem |
Lorem |
| Lorem |
Lorem |
Lorem |
Lorem |
Trade Names
| Country |
Trade Name |
Vendor |
Annotation |
| USA |
Lorem |
Lorem
|
|
| J |
Lorem |
Lorem
|
|
(wfm = withdrawn from market)
Formulations
- Loremipsumdolorsitamet,consetetursadipscing
References
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- US 9 999 999 (Eisai R&D management; 29.05.2012; JP-prior. 22.09.2010).
- EP 9 999 999 (Eisai R&D management; 15.04.2015; JP-prior. 22.09.2010).
- US 99 999 999 (Eisai R&D management; 29.01.2019; JP-prior. 23.10.2014).
- EP 9 999 999 (Eisai R&D management; 02.12.2020; JP-prior. 23.10.2014).
- WO 9999 999999 (Eisai R&D management; 19.11.2019; JP-prior. 15.05.2019).
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Alternative preparation of Lemborexant:
- Clemenceau, A. et al., J. Am. Chem. Soc., (2020) 142, 15355-15361.
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Method for manufacturing cyclopropane compound:
- WO 9999 999999 (Sumitomo Chemical Comp.; 12.03.2020; JP-prior. 07.09.2018).
