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Lefamulin
  • Synonyms: BC-3781
  • ATC: J01XX12
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:507.73 g/mol
  • CAS-RN:1061337-51-6
  • InChI Key:KPVIXBKIJXZQJX-CSOZIWFHSA-N
  • InChI:InChI=1S/C28H45NO5S/c1-​6-​26(4)​14-​22(34-​23(32)​15-​35-​21-​8-​7-​18(29)​13-​20(21)​31)​27(5)​16(2)​9-​11-​28(17(3)​25(26)​33)​12-​10-​19(30)​24(27)​28/h6,​16-​18,​20-​22,​24-​25,​31,​33H,​1,​7-​15,​29H2,​2-​5H3/t16?,​17-,​18+,​20+,​21+,​22+,​24-,​25-,​26+,​27-,​28-​/m0/s1

Derivatives

    Acetate

  • Formula: C30H49NO7S
  • MW:567.8 g/mol
  • CAS-RN:1350636-82-6

Substance Classes

Synthesis Path

  • The starting material Pleuromutilin is produced by fermentation of the basidiomycetes Pleurotus mutilus and Pleurotus passeckerianus.



Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
125-65-5 C22H34O5 Pleuromutilin
31716-01-5 C26H40O7S 22-O-tosylpleuromutilin
C11H21NO3S tert-butyl[(1R,3R,4R)-3-hydroxy-4-mercapto-cyclohexyl]-carbamate
C23H53NO7S 14-O-{[(1R,2R,4R)-4-tert-butoxycarbonylamino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
EU Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,

References

    • Chem. & Engng. News (CEN), 22.06.2020, p. 31-36.
    • Flick, A.C. et al., J. Med. Chem., (2021) 64, 3604-3657: Synthetic approaches to the new drugs approved during 2019.
    • US 9 999 999 (Biochemie GmbH, Kundl; 22.06.2004; GB-prior. 11.07.2000).
    • US 9 999 999 (Nabriva; 06.12.2011; EP-prior. 20.03.2007).
    • US 9 999 999 (Nabriva; 10.04.2012; EP-prior. 20.03.2007).
    • US 9 999 999 (Nabriva; 01.09.2015; EP-prior. 26.05.2010).

  • Injectable formulation:

    • EP 9 999 999 (Nabriva; 14.10.2020; USA-prior. 17.06.2015).

  • Pleuromutilin by fermentation:

    • Kavanagh, F. et al., Proc. Natl. Acad. Sci. USA (PNASA6), (1951) 37, 570-574.

  • Purification of Pleuromutilin:

    • WO2018 999999 A1 (Nabriva; publ. 16.08.2018 ; EP-prior. 10.02.2017).
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