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Medroxyprogesterone acetate

  • Synonyms: MPA
  • ATC: G03AC06; G03DA02; L02AB02
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:386.53 g/mol
  • CAS-RN:71-58-9
  • InChI Key:PSGAAPLEWMOORI-PEINSRQWSA-N
  • InChI:InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
  • EINECS:200-757-9
  • LD50: >16 g/kg (M, p.o.);
    >6.4 g/kg (R, p.o.);
    >5 g/kg (dog, p.o.)

Substance Classes

Synthesis Path












Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
108-24-7 C4H6O3 acetic anhydride Acetic acid, anhydride
23706-51-6 C22H34O4 5α,17α-dihydroxy-3,20-dioxo-6β-methylpregnane 5α-Pregnane-3,20-dione, 5,17-dihydroxy-6β-methyl-
3386-01-4 C26H42O6 5,17-dihydroxy-6β-methyl-5α-pregnane-3,20-dione cyclic bis(ethylene acetal) 5α-Pregnane-3,20-dione, 5,17-dihydroxy-6β-methyl-, cyclic bis(ethylene acetal)
3496-78-4 C25H38O6 (5α,6α)-5,6-epoxy-17-hydroxypregnane-3,20-dione cyclic bis(1,2-ethanediyl acetal) Pregnane-3,20-dione, 5,6-epoxy-17-hydroxy-, cyclic bis(1,2-ethanediyl acetal), (5α,6α)-
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem comb.
Lorem Lorem
Lorem Lorem comb.
Lorem Lorem comb.
Lorem Lorem
Lorem Lorem comb.
Lorem Lorem comb.
Lorem ipsum
F Lorem Lorem
Lorem Lorem
Lorem Lorem
GB Lorem Lorem
I Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem ipsum dolor
USA Lorem Lorem
Lorem Lorem
Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,seddiamvoluptua.Atveroeosetaccusamet

References

    •  Ellis, B. et al.: J. Chem. Soc. (JCSOA9) 1957, 4092.
    • a US 9 999 999 (Upjohn; 1.9.1964; appl. 17.5.1961; prior. 23.11.1956).
  • starting material: cf. literature cited under a

    •  Babcock, J.C. et al.: J. Am. Chem. Soc. (JACSAT) 80, 2904 (1958).
    • b US 9 999 999 (Societa Farmaceutici Italia; 30.10.1962; appl. 17.9.1958; GB-prior. 24.4.1958).
    •  DE 9 999 999 (Syntex; appl. 29.8.1957; Mex-prior. 8.9.1956).
  • starting material:

    • Bernstein, S. et al.: J. Am. Chem. Soc. (JACSAT) 76, 5674 (1954).
    • The Merck Index, 4756 (Rahway 1976).
  • alternative syntheses:

    • DE 9 999 999 (British Drug Houses; appl. 21.8.1958; GB-prior. 13.8.1957).
    • DE 9 999 999 (Searle; appl. 24.9.1958; USA-prior. 27.9.1957).
    • US 9 999 999 (Ormonoterapia Richter; 10.7.1962; appl. 28.4.1961; I-prior. 27.2.1961).
  • review:

    • Ehrhardt, Ruschig III, 352.