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Nalmefene
  • Synonyms: NIH-10365, Nalmetrene (base), JF-1, ORF-11676
  • ATC: N07BB05
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:339.44 g/mol
  • CAS-RN:55096-26-9
  • InChI Key:WJBLNOPPDWQMCH-MBPVOVBZSA-N
  • InChI:InChI=1S/C21H25NO3/c1-​12-​6-​7-​21(24)​16-​10-​14-​4-​5-​15(23)​18-​17(14)​20(21,​19(12)​25-​18)​8-​9-​22(16)​11-​13-​2-​3-​13/h4-​5,​13,​16,​19,​23-​24H,​1-​3,​6-​11H2/t16-,​19+,​20+,​21-​/m1/s1

Derivatives

    monohydrochloride

  • Formula: C21H25NO3 • HCl
  • MW:375.90 g/mol
  • CAS-RN:58895-64-0

    (+)-base

  • Formula: C21H25NO3
  • MW:339.44 g/mol
  • CAS-RN:131378-67-1

    (+)-monohydrochloride

  • Formula: C21H25NO3 • HCl
  • MW:375.90 g/mol
  • CAS-RN:131712-55-5

Substance Classes

Synthesis Path

Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
1779-49-3 C19H18BrP methyltriphenylphosphonium bromide Phosphonium, methyltriphenyl-, bromide
16590-41-3 C20H23NO4 naltrexone Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5α)-

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,

References

    • Hahn, F.E. et al.: J. Med. Chem. (JMCMAR) 18, 999 (1975).

  • synthesis of nalmefene from naltrexone:

    • US 9 999 999 (Nat. Inst. of Health; appl. 28.8.1990; USA-prior. 26.10.1989).
    • US 9 999 999 (Du Pont de N.; appl. 30.3.1982; USA-prior. 28.4.1980).
    • US 9 999 999 (Mallinckrodt, Inc.; appl. 27.2.1987; USA-prior. 17.1.1985).
    • EP 999 999 (Key Pharm. Inc.; appl. 8.5.1985; USA-prior. 1.11.1983).

  • use of nalmefene:

    • US 9 999 999 (Baker Cummins Pharm.; appl. 14.11.1989; USA-prior. 22.7.1988).
    • WO 9 999 999 (Baker Cummins Pharm.; appl. 2.11.1989; USA-prior. 27.4.1988).
    • WO 9 999 999 (Key Pharmaceuticals; appl. 7.5.1987; 29.1.1985).
    • US 9 999 999 (Key Pharmaceuticals; appl. 27.1.1987; USA-prior. 2.1.1984).
    • US 9 999 999 (Baker Cummins Pharm.; appl. 5.9.1989; USA-prior. 4.1.1989).
    • US 9 999 999 (Baker Cummins Pharm.; appl. 31.10.1989; USA-prior. 1.11.1988).
    • US 9 999 999 (Baker Cummins Pharm.; appl. 8.5.1990; 10.7.1989).
    • WO 9 999 999 (Baker Cummins Pharm.; appl. 29.10.1992; USA-prior. 10.4.1991).
    • WO 9 999 999 (Finland; appl. 12.12.1991; USA-prior. 4.6.1990).

  • formulation:

    • US 9 999 999 (Key Pharmaceuticals; appl. 16.4.1985; 28.3.1983).

  • combination:

    • WO 9 999 999 (Italy; appl. 30.11.1995; I-prior. 24.5.1994).
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