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Tenofovir alafenamide
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Synonyms:
GS-7340; TAF; prodrug of Tenofovir
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ATC:
J05AR17; J05AR18; J05AR19; J05AF13
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Use:
Lorem
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Chemical name:
Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
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Formula:
Lorem ipsum dolor sit amet,
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MW:476.5 g/mol
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CAS-RN:379270-37-8
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InChI Key:LDEKQSIMHVQZJK-CAQYMETFSA-N
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InChI:InChI=1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1
Derivatives
Fumarate
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Formula:
C21H29N6O5P • C4H4O4
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MW:534.5 g/mol
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CAS-RN:1392275-56-7
Synthesis Path
Substances Referenced in Synthesis Path
| CAS-RN |
Formula |
Chemical Name |
CAS Index Name |
| 134461-75-9 |
C5H5N5 |
adenine |
|
| 16606-55-6 |
C4H6O3 |
(R)-4-methyl-1,3-dioxolan-2-one |
|
| 14047-28-0 |
C8H11N5O |
(R)-9-(2-hydroxypropyl)adenine |
|
| 31618-90-3 |
C12H19O6PS |
p-toluenesulfonyloxy-methylphosphonate |
|
| Lorem |
Lorem |
Lorem |
Lorem |
| Lorem |
Lorem |
Lorem |
Lorem |
| Lorem |
Lorem |
Lorem |
Lorem |
Trade Names
| Country |
Trade Name |
Vendor |
Annotation |
| USA |
Lorem |
Lorem
|
in combination with Emtricitabine |
| Lorem |
Lorem
|
in combination with Cobicistat, Elvitegravir and Emtricitabine |
| Lorem |
Lorem
|
in combination with Emtricitabine and Rilpivirine |
| Lorem |
Lorem
|
|
| EU |
Lorem |
Lorem
|
in combination with Emtricitabine |
| Lorem |
Lorem
|
in combination with Cobicistat, Elvitegravir and Emtricitabine |
| Lorem |
Lorem
|
in combination with Emtricitabine and Rilpivirine |
| Lorem |
Lorem
|
|
(wfm = withdrawn from market)
Formulations
- Loremipsumdolorsitamet,consetetursadipscingelitr,sed
References
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- US 9 999 999 (Gilead Sciences, 24.6.2008; appl. 11.3.2004; USA-prior. 21.7.2000).
- US 9 999 999 (Gilead Sciences, 28.9.2010; appl. 28.4.2008; USA-prior. 21.7.2000).
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Tenofovir alafenamide hemifumarate:
- US 9 999 999 (Gilead Sciences, 29.3.2016; appl. 5.3.2014; USA-prior. 16.8.2014).
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Improved process:
- WO 9999 999999 (Laurus Labs., 26.3.2015; appl. 22.9.2014; IN-prior. 20.9.2013).
