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Tucatinib

  • Synonyms: Irbinitinib; ONT-380; ARRY-380
  • ATC: L01EH03
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:480.5 g/mol
  • CAS-RN:937263-43-9
  • InChI Key:SDEAXTCZPQIFQM-UHFFFAOYSA-N
  • InChI:InChI=1S/C26H24N8O2/c1-16-10-17(5-7-22(16)36-19-8-9-34-23(12-19)28-15-30-34)31-24-20-11-18(4-6-21(20)27-14-29-24)32-25-33-26(2,3)13-35-25/h4-12,14-15H,13H2,1-3H3,(H,32,33)(H,27,29,31)

Derivatives

    Hemiethanolate

  • Formula: C26H24N8O2 • 1/2C2H5OH
  • MW:503.6 g/mol
  • CAS-RN:

Substance Classes

Synthesis Path










Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
99-53-6 C7H7NO3 2-methyl-4-nitrophenol
19798-80-2 C5H5ClN2 2-amino-4-chloropyridine
864244-98-4 C12H11N3O3 4-(2-methyl-4-nitrophenoxy)-pyridine-2-amine
4637-24-5 C5H13NO2 dimethoxy-N,N-dimethylmethanamine
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Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
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Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,

References

    • b) Yin, L. et al., Synthesis, (2019) 51(13), 2660-2664.
    • Kocienski, P., Synfacts, (2019) 15(09), 6965.
    • a) US 9 999 999 (Array Biopharma; 11.2.2014; appl. 15.11.2006; USA-prior. 15.11.2005).
    • US 9 999 999 (Array Biopharma; 4.7.2017; appl. 23.9.2013; USA-prior. 15.11.2005).
  • Polymorphs of ARRY-380:

    • US 99 999 999 (Array Biopharma; 4.12.2018; appl. 3.1.2018; USA-prior. 14.11.2011).
  • Solid dispersion of a HER-2 inhibitor:

    • US 9999 9999999 (Array Biopharma; 18.9.2017; appl. 23.9.2016; USA-prior. 12.10.2012).
  • Combination therapy:

    • US 9999 999999 (Cascadian Therapeutics; 111.2018; appl. 27.4.2018; USA-prior. 28.4.2017).