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Tucatinib
  • Synonyms: Irbinitinib; ONT-380; ARRY-380
  • ATC: L01EH03
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:480.5 g/mol
  • CAS-RN:937263-43-9
  • InChI Key:SDEAXTCZPQIFQM-UHFFFAOYSA-N
  • InChI:InChI=1S/C26H24N8O2/c1-​16-​10-​17(5-​7-​22(16)​36-​19-​8-​9-​34-​23(12-​19)​28-​15-​30-​34)​31-​24-​20-​11-​18(4-​6-​21(20)​27-​14-​29-​24)​32-​25-​33-​26(2,​3)​13-​35-​25/h4-​12,​14-​15H,​13H2,​1-​3H3,​(H,​32,​33)​(H,​27,​29,​31)

Derivatives

    Hemiethanolate

  • Formula: C26H24N8O2 • 1/2C2H5OH
  • MW:503.6 g/mol
  • CAS-RN:

Substance Classes

Synthesis Path






Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
99-53-6 C7H7NO3 2-methyl-4-nitrophenol
19798-80-2 C5H5ClN2 2-amino-4-chloropyridine
864244-98-4 C12H11N3O3 4-(2-methyl-4-nitrophenoxy)-pyridine-2-amine
4637-24-5 C5H13NO2 dimethoxy-N,N-dimethylmethanamine
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,

References

    • a) US 9 999 999 (Array Biopharma; 11.2.2014; appl. 15.11.2006; USA-prior. 15.11.2005).
    • US 9 999 999 (Array Biopharma; 4.7.2017; appl. 23.9.2013; USA-prior. 15.11.2005).
    • b) Yin, L. et al., Synthesis, (2019) 51(13), 2660-2664.
    • Kocienski, P., Synfacts, (2019) 15(09), 6965.

  • Polymorphs of ARRY-380:

    • US 99 999 999 (Array Biopharma; 4.12.2018; appl. 3.1.2018; USA-prior. 14.11.2011).

  • Solid dispersion of a HER-2 inhibitor:

    • US 9999 9999999 (Array Biopharma; 18.9.2017; appl. 23.9.2016; USA-prior. 12.10.2012).

  • Combination therapy:

    • US 9999 999999 (Cascadian Therapeutics; 111.2018; appl. 27.4.2018; USA-prior. 28.4.2017).
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