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Tivozanib
  • Synonyms: AV-951; KRN951
  • ATC: L01EK03
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:454.87 g/mol
  • CAS-RN:475108-18-0
  • InChI Key:SPMVMDHWKHCIDT-UHFFFAOYSA-N
  • InChI:InChI=InChI=1S/C22H19ClN4O5/c1-​12-​8-​21(27-​32-​12)​26-​22(28)​25-​16-​5-​4-​13(9-​15(16)​23)​31-​18-​6-​7-​24-​17-​11-​20(30-​3)​19(29-​2)​10-​14(17)​18/h4-​11H,​1-​3H3,​(H2,​25,​26,​27,​28)

Derivatives

    Hydrochloride monohydrate

  • Formula: C22H22Cl2N4O6
  • MW:509.3 g/mol
  • CAS-RN:682745-41-1

Substance Classes

Synthesis Path



Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
4101-30-2 C10H13NO3 4-amino-4,5-dimethoxyacetophenone
35654-56-9 C11H10ClNO2 4-chloro-6,7-dimethoxyquinoline
17609-80-2 C6H6ClNO 4-amino-3-chlorophenol
C17H15ClN2O3 4-[(4-amino-3-chlorophenol)oxy]-6,7-dimethoxyquinoline
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
EU Lorem Lorem
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumy

References

    • a) Kubo, K. et al., J. Med. Chem., (2005) 48, 1359-1366.
    • US 9 999 999 (Kirin Brewery; 23.11.2004; appl. 26.4.2002; JP-prior. 27.4.2001).
    • US 9 999 999 (Kirin Brewery; 23.1.2007; appl. 21.10.2003; JP-prior. 21.10.2002).
    • b) Zhu, C., et al., Heterocycles, (2016) 92(10), 1882-1887.

  • Use of combination:

    • US 9 999 999 (Eisai; 26.8.2014; appl. 8.8.2011; JP-prior. 7.11.2005).
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