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Viloxazine
  • Synonyms: SPN-812
  • ATC: N06AX09
  • Use: Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:237.30 g/mol
  • CAS-RN:46817-91-8
  • InChI Key:YWPHCCPCQOJSGZ-UHFFFAOYSA-N
  • InChI:InChI=1S/C13H19NO3/c1-​2-​15-​12-​5-​3-​4-​6-​13(12)​17-​10-​11-​9-​14-​7-​8-​16-​11/h3-​6,​11,​14H,​2,​7-​10H2,​1H3
  • EINECS:256-281-7
  • LD50: 60 mg/kg (M, i.v.); 552 mg/kg (M, p.o.);
    60 mg/kg (R, i.v.); 2 g/kg (R, p.o.)

Derivatives

    hydrochloride

  • Formula: C13H19NO3 • HCl
  • MW:273.76 g/mol
  • CAS-RN:35604-67-2
  • EINECS:252-638-6
  • LD50: 60 mg/kg (M, i.v.); 480 mg/kg (M, p.o.);
    60 mg/kg (R, i.v.); 2 g/kg (R, p.o.)

Substance Classes

Synthesis Path






Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
926-39-6 C2H7NO4S 2-aminoethyl hydrogen sulfate Ethanol, 2-amino-, hydrogen sulfate (ester)
100-46-9 C7H9N benzylamine Benzenemethanamine
79-04-9 C2H2Cl2O chloroacetyl chloride Acetyl chloride, chloro-
106-89-8 C3H5ClO epichlorohydrin Oxirane, (chloromethyl)-
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem ,1977
F Lorem Lorem ,1977
Lorem ipsum Lorem
GB Lorem Lorem ,1974
I Lorem Lorem wfm
J Lorem Lorem
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,seddiamvoluptua.Atveroeosetaccusam

References

    • a GB 9 999 999 (ICI; appl. 28.12.1966; valid from 13.11.1967).
    •  US 9 999 999 (ICI; 30.1.1973; GB-prior. 28.12.1966).
    •  US 9 999 999 (ICI; 8.4.1975; prior. 24.11.1967).
    •  DOS 9 999 999 (ICI; appl. 24.11.1967; GB-prior. 28.12.1966).
    • b US 9 999 999 (ICI; 31.12.1974; GB-prior. 20.6.1969, 13.10.1969).
    •  US 9 999 999 (ICI; 23.1.1973; GB-prior. 20.6.1969; 13.10.1969).
    •  Greenwood, D.T. et al.: J. Med. Chem. (JMCMAR) 18, 999 (1975).

  • Methods for producing Viloxazine salts and novel polymorphs:

    • US 9999 9999999 (Supernus Pharmas.; 20.9.2018; appl. 24.5.2018; USA-prior. 12.4.2011).

  • Modified release formulations:

    • US 9 999 999 (Supernus Pharmas.; 7.6.2016; appl. 7.2.2013; USA-prior. 8.2.2012).
    • US 9 999 999 (Supernus Pharmas.; 30.5.2017; appl. 3.6.2016; USA-prior. 8.2.2012).
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