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Vinorelbine
  • Synonyms: 5'-Noranhydrovinblastine, PM259
  • ATC: L01CA04
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:778.95 g/mol
  • CAS-RN:71486-22-1
  • InChI Key:GBABOYUKABKIAF-IELIFDKJSA-N
  • InChI:InChI=1S/C45H54N4O8/c1-​8-​27-​19-​28-​22-​44(40(51)​55-​6,​36-​30(25-​48(23-​27)​24-​28)​29-​13-​10-​11-​14-​33(29)​46-​36)​32-​20-​31-​34(21-​35(32)​54-​5)​47(4)​38-​43(31)​16-​18-​49-​17-​12-​15-​42(9-​2,​37(43)​49)​39(57-​26(3)​50)​45(38,​53)​41(52)​56-​7/h10-​15,​19-​21,​28,​37-​39,​46,​53H,​8-​9,​16-​18,​22-​25H2,​1-​7H3/t28-,​37-,​38+,​39+,​42+,​43+,​44-,​45-​/m0/s1
  • LD50:26 mg/kg (M, i.p.)

Derivatives

    hydrogen tartrate (1:1)

  • Use:
  • Formula: Lorem ipsum dolor sit amet,
  • MW:929.03 g/mol
  • CAS-RN:105661-07-2

    tartrate

  • Use:
  • Formula: Lorem ipsum dolor sit amet,
  • MW:1079.12 g/mol
  • CAS-RN:125317-39-7

Substance Classes

Synthesis Path






Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
38390-45-3 C46H56N4O8 anhydrovinblastine Vincaleukoblastine, 3',4'-didehydro-4'-deoxy-
C50H56F6N4O12 3',4'-didehydro-4'-deoxy-6'-[(trifluoroacetyl)oxy]vincaleukoblastinium mono(trifluoroacetate)
60332-19-6 C46H56N4O9 3',4'-didehydro-4'-deoxyvincaleukoblastine 6'-oxide Vincaleukoblastine, 3',4'-didehydro-4'-deoxy-, 6'-oxide
74816-86-7 C50H56F6N4O12 3',4',6',7',8',9',16',17'-octadehydro-4'-deoxy-9',17'-dihydro-7',8'-secovincaleukoblastinium mono(trifluoroacetate), salt with trifluoroacetic acid 7',8'-Secovincaleukoblastinium, 3',4',6',7',8',9',16',17'-octadehydro-4'-deoxy-9',17'-dihydro-, salt with trifluoroacetic acid (1:1), mono(trifluoroacetate)
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem
Lorem Lorem
F Lorem Lorem
GB Lorem Lorem
I Lorem Lorem
J Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyam

References

    • US 9 999 999 (ANVAR; 22.12.1981; F-prior. 24.8.1978, 6.2.1979).
    • EP 99 999 (ANVAR Agence Nat. Valorisation; F-prior. 24.8.1978, 6.2.1979).
    • Andriamialisoa, R.Z. et al.: Tetrahedron (TETRAB) 36, 99 (1980).
    • Mangeney, P. et al.: Tetrahedron (TETRAB) 35, 9999 (1979); J. Org. Chem. (JOCEAH) 44, 9999 (1979).
    • Gueritte, F. et al.: Eur. J. Med. Chem. (EJMCA5) 18, 999 (1983).
    • Potier, P.: Semin. Oncol. (SOLGAV) 16, (2. Suppl. 4), 9 (1989); J. Nat. Prod. (JNPRDF) 43, 99 (1980).

  • pharmaceutical formulation for parenteral administration:

    • EP 999 999 (PierreFabre; appl. 10.11.1988; F-prior. 13.11.1987).

  • synthesis of anhydrovinblastine:

    • US 9 999 999 (Eli Lilly; 14.6.1977; appl. 10.7.1975).
    • EP 999 999 (Mitsui Petrochem.; appl. 9.8.1989; J-prior. 11.8.1988).
    • DOS 9 999 999 (Univ. of British Columbia; appl. 6.8.1988; CND-prior. 6.8.1987).
    • FR 9 999 999 (Pierre Fabre; appl. 14.4.1983).
    • HU 99 999 (Richter Gedeon; appl. 17.3.1977).
    • WO 9 999 999 (Mitsui Petrochem.; appl. 16.9.1987; USA-prior. 18.9.1986).
    • JP 99 999 999 (Mitsui Petrochem.; appl. 4.8.1987; USA-prior. 4.8.1986).
    • Kutney, J.P. et al.: Helv. Chim. Acta (HCACAV) 58, 1690, 9999 (1975); 59, 9999 (1976).
    • Raucher, S. et al.: J. Am. Chem. Soc. (JACSAT) 109, 999 (1987).
    • Kutney, J.P. et al.: Heterocycles (HTCYAM) 27, 621, 9999 (1988).
    • Goodbody, A.E. et al.: Planta Med. (PLMEAA) 54, 136, 999 (1988).
    • Vokovic, J. et al.: Tetrahedron (TETRAB) 44, 999 (1988).
    • Atta-Ur-Rahman, P.S.: J. Nat. Prod. (JNPRDF) 51, 9999 (1988).
    • Bray, B.L.: Dissertation Univ. Washington (Seattle), Diss. Abstr. Int. B 1988, 99 (12), Pt. 1, 3567.
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