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Vibegron
  • Synonyms: MK-4618; KRP-114V
  • ATC: -
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:444.54 g/mol
  • CAS-RN:1190389-15-1
  • InChI Key:DJXRIQMCROIRCZ-XOEOCAAJSA-N
  • InChI:InChI=1S/C26H28N4O3/c31-​24-​14-​15-​27-​23-​13-​12-​22(30(23)​24)​26(33)​29-​19-​8-​6-​17(7-​9-​19)​16-​20-​10-​11-​21(28-​20)​25(32)​18-​4-​2-​1-​3-​5-​18/h1-​9,​14-​15,​20-​22,​25,​28,​32H,​10-​13,​16H2,​(H,​29,​33)/t20-,​21+,​22-,​25+/m0/s1

Substance Classes

Synthesis Path












Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
5680-79-5 C3H8ClNO2 glycine methyl ester hydrochloride
C15H19NO5 methyl 2-((tert-butoxycarbonyl)-amino)-3-oxo-3-phenylpropanoate
C15H21NO5 methyl 2-((tert-butoxycarbonyl)-amino)-3-hydroxy-3-phenylpropanoate
C5H12O2 Dimethoxypropane
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolor

References

    • Edmondson, S.D. et al., "Discovery of Vibegron", J. Med. Chem., (2016) 59, 609-623.
    • Xu, F. et al., Org. Lett., (2013) 15, 1342-1345.
    • Xu, F. et al., Angew. Chem. Int. Ed., (2018) 57, 6863-6867.
    • US 9 999 999 (Merck Sharp & Dohme; 21.08.2012; USA-prior. 04.04.2008).
    • US 9 999 999 (Merck Sharp & Dohme; 19.03.2013; USA-prior. 04.04.2008).
    • US 9 999 999 (Merck Sharp & Dohme; 18.02.2014; USA-prior. 04.04.2008).

  • Process:

    • US 9 999 999 (Merck Sharp & Dohme; 07.11.2017; USA-prior. 27.10.2011).
    • US 9 999 999 (Merck Sharp & Dohme; 21.11.2017; USA-prior. 27.10.2011).
    • US 99 999 999 (Merck Sharp & Dohme; 14.05.2019; USA-prior. 15.03.2013).
    • EP 9 999 999 (Merck Sharp & Dohme; 10.07.2019; USA-prior. 15.03.2013).

  • Med. Use:

    • WO 9999 999999 (Urovant Sciences; publ. 13.12.2018; USA-prior. 06.06.2017).
    • WO 9999 999999 (Urovant Sciences; publ. 13.12.2018; USA-prior. 06.06.2017).
    • WO 9999 999999 (Urovant Sciences; publ. 11.06.2020 ; USA-prior. 05.12.2018).
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