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Zileuton
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Synonyms:
A-64077, ABT-077
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Use:
Lorem
Lorem
Lorem
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Chemical name:
Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
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Formula:
Lorem ipsum dolor sit amet,
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MW:236.30 g/mol
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CAS-RN:111406-87-2
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InChI Key:MWLSOWXNZPKENC-UHFFFAOYSA-N
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InChI:InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
Substances Referenced in Synthesis Path
CAS-RN |
Formula |
Chemical Name |
CAS Index Name |
75-07-0 |
C2H4O |
acetaldehyde |
Acetaldehyde |
22720-75-8 |
C10H8OS |
2-acetylbenzo[b]thiophene |
Ethanone, 1-benzo[b]thien-2-yl- |
118564-89-9 |
C10H11NOS |
N-[1-(benzo[b]thien-2-yl)ethyl]hydroxylamine |
Benzo[b]thiophene-2-methanamine, N-hydroxy-α-methyl- |
95-15-8 |
C8H6S |
benzo[b]thiophene |
Benzo[b]thiophene |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Trade Names
Country |
Trade Name |
Vendor |
Annotation |
USA |
Lorem |
Lorem
|
|
(wfm = withdrawn from market)
References
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- a US 9 999 999 (Abbott; 10.10.1989; appl. 11.1.1988; USA-prior. 10.2.1987, 10.6.1987).
- EP 999 999 (Abbott Lab.; appl. 1.2.1988; USA-prior. 10.2.1987).
- EP 999 999 (Abbott Lab.; appl. 6.9.1990; USA-prior. 7.9.1989).
- Brooks, C.D. W. et al.: J. Med. Chem. (JMCMAR) 38, 9999 (1995).
- b EP 999 999 (Elf Sanofi; appl. 21.9.1993; F-prior. 22.9.1992).
- c Stewart, A.O.; Brooks, D.W.: J. Org. Chem. (JOCEAH) 57, 9999 (1992).
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alternative synthesis:
- Ku, Y.-Y. et al.: Tetrahedron Lett. (TELEAY) 35 (33), 9999 (1994).
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preparation of trimethylsilylisocyanate:
- Kijima, J. at al.: Nippon Kagaku Kaishi (NKAKB8) 7, 1157-60 (1989),
- EP 99 999 (Bayer AG; appl. 25.5.1982; D-prior. 3.6.1981).
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use as anticancer agent:
- WO 9 999 999 (US Dept. Health; appl. 14.3.1995; USA-prior. 14.3.1994).
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use for treatment of neurodegenerative diseases:
- WO 9 999 999 (Università Brescia; appl. 13.11.1997; I-prior. 13.11.1996).
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combinations with COX-2-inhibitors:
- WO 9 999 999 (G. D. Searle and Co.; appl. 11.6.1996; USA-prior. 12.6.1995).
- WO 9 999 999 (G. D. Searle and Co.; appl. 12.2.1997; USA-prior. 13.2.1996).