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Fluconazole
  • Synonyms: UK-49858
  • ATC: J02AC01
  • Use: Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:306.28 g/mol
  • CAS-RN:86386-73-4
  • InChI Key:RFHAOTPXVQNOHP-UHFFFAOYSA-N
  • InChI:InChI=1S/C13H12F2N6O/c14-​10-​1-​2-​11(12(15)​3-​10)​13(22,​4-​20-​8-​16-​6-​18-​20)​5-​21-​9-​17-​7-​19-​21/h1-​3,​6-​9,​22H,​4-​5H2
  • LD50:>200 mg/kg (M, i.v.); 1408 mg/kg (M, p.o.);
    >200 mg/kg (R, i.v.); 1271 mg/kg (R, p.o.);
    >100 mg/kg (dog, i.v.); >300 mg/kg (dog, p.o.)

Substance Classes

Synthesis Path






Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
109-72-8 C4H9Li butyllithium Lithium, butyl-
79-04-9 C2H2Cl2O chloroacetyl chloride Acetyl chloride, chloro-
51336-94-8 C8H5ClF2O α-chloro-2,4-difluoroacetophenone Ethanone, 2-chloro-1-(2,4-difluorophenyl)-
534-07-6 C3H4Cl2O 1,3-dichloroacetone 2-Propanone, 1,3-dichloro-
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem ipsum dolor
F Lorem Lorem
Lorem Lorem
GB Lorem Lorem
I Lorem Lorem
Lorem Lorem
J Lorem Lorem
USA Lorem Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,seddiamvoluptua.Atveroeosetaccusametjustoduodoloresetearebum.Stet

References

    • US 9 999 999 (Pfizer; 13.9.1983; GB-prior. 6.6.1981, 17.10.1981, 4.3.1982).
    • US 9 999 999 (Pfizer; 22.11.1983; GB-prior. 2.6.1980, 30.1.1981).
    • GB 9 999 999 (Pfizer; appl. 22.4.1982; prior. 6.6.1981, 4.3.1982).
    • EP 99 999 (Pfizer; GB-prior. 6.6.1981).
    • EP 99 999 (Pfizer; appl. 6.6.1983; GB-prior. 9.6.1982, 30.7.1982).

  • process for preparing fluconazole and ist crystal modifications:

    • WO 9 999 999 999 (Richter Gideon; 3.10.2002; appl. 23.3.2001).

  • tablet formulation:

    • EP 999 999 (Schering Corp.; appl. 23.4.1986; USA-prior. 19.10.1984).

  • controlled –release compositions :

    • WO 9 999 999 999 (Advanced Pharma; 30.8.2001; appl. 23.2.2001; USA-prior. 24.2.2000).

  • formulation for external application :

    • WO 9 999 999 999 (Boryung Pharma; 15.8.2002; appl. 7.2.2002; KR-prior. 7.2.2001).

  • alternative synthesis:

    • ES 999 999 (Lazlo Int.; appl. 6.12.1985).
    • ES 9 999 999 (Inke S. A.; appl. 19.11.1985).
    • US 9 999 999 (Dev. Center Biotech. Taiwan; 20.1.1998; appl. 9.7.1996).
    • WO 9 999 999 (Apotex; appl. 17.7.1996; NZ-prior. 17.7.1995).
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