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Levoleucovorin

  • Synonyms: Levofolinic acid; L-Folinic acid; Levofolene; (S)-Leucovorin; Citrovorum factor
  • ATC: V03AF04 (Calcium salt)
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:473.4 g/mol
  • CAS-RN:6853885-2
  • InChI Key:VVIAGPKUTFNRDU-OLZOCXBDSA-N
  • InChI:InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13+/m1/s1

Derivatives

    Calcium salt

  • Formula: C20H21CaN7O7
  • MW:511.5 g/mol
  • CAS-RN:80433-71-2

Substance Classes

Synthesis Path




Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
C19H19N7O6 Folic acid
C19H23N7O6 (6-R,S)-tetrahydrofolic acid
C19H23N7O6 (6R)-tetrahydrofolic acid

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
Lorem Lorem
Lorem ipsum dolor
D Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumy

References

    • EP-appl. 999 999 A1 (Eprova; publ. 22.07.1992; CH-prior. 16.01.1991).
  • Hydrogenation of folic acid with noble metal catalysts:

    • US 9 999 999 (Mitsui Toatsu; 1987; JP-prior. 1984).
  • Reduction of folic acid with NaBH4:

    • Temple, C. et al., J. Med. Chem., (1979) 22, 731.
  • Fractional crystallization of Calcium folinate at pH 8.5 - 12:

    • US 9 999 999 (Eprova; 1992; CH-prior. 1987).