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Remdesivir

  • Synonyms: GS-5734; prodrug of GS-441524
  • ATC: -
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:602.59 g/mol
  • CAS-RN:1809249-37-3
  • InChI Key:RWWYLEGWBNMMLJ-YSOARWBDSA-N
  • InChI:InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1

Substance Classes

Synthesis Path













Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
89615-45-2 C26H28O5 (3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolan-2-ol; (2,3,5-Tri-O-benzyl-α-D-ribofuranose)
55094-52-5 C26H26O5 (3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]dihydrofuran-2(3H)-one
C6H5BrN4 7-bromopyrrolo[2,1-f][1,2,4]triazin-4-amine
C32H32N4O5 (3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-[(benzyloxy)-methyl]tetrahydrofuran-2-ol
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Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA On 1 May 2020 FDA granted Gilead Sciences an Emergency Use Authorization of remdesivir to be distributed and used by licensed health care providers to treat hospitalized patients with severe COVID-19.
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiam

References

    • Warren, T.K. et al., Nature, (2016) 531 (7594), 381-385.
    • Grein, J. et al., NEJM April 10, 2020; doi 10.1056/NEJMoa 2007016.
    • Avataneo, V. et al., J. Antimicrob. Chemother, May 3, 2020; doi 10.1093/jac/dkaa 152.
    • a+b) Siegel, D. et al., J. Med. Chem., (2017) 60, 1648-1661.
    • US 9 999 999 (Gilead Sciences; 8.8.2017; appl. 29.10.2015; USA-prior. 29.10.2014).
  • Methods for treating arenaviridae and coronaviridae virus infections:

    • US 9999 9999999 (Gilead Sciences; 16.3.2017; appl. 16.9.2016; USA-prior. 16.9.2015).
  • Crystalline forms:

    • US 9999 999999 (Gilead Sciences; 6.12.2018; appl. 27.4.2018; USA-prior. 1.5.2017).
  • Compositions comprising an RNA polymerase inhibitor:

    • US 9999 999999 (Gilead Sciences; 21.3.2019; appl. 10.7.2018; USA-prior. 11.7.2017).