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Semaglutide

  • Synonyms: NN-9535
  • ATC: A10BJ06
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:4113.6 g/mol
  • CAS-RN:910463-68-2
  • InChI Key:DLSWIYLPEUIQAV-CCUURXOWSA-N
  • InChI:InChI=1S/C187H291N45O59/c1-18-105(10)154(180(282)208-108(13)159(261)216-133(86-114-89-200-119-50-40-39-49-117(114)119)170(272)218-129(82-102(4)5)171(273)228-152(103(6)7)178(280)215-121(53-44-72-199-186(192)193)162(264)201-91-141(242)209-120(52-43-71-198-185(190)191)161(263)204-94-151(257)258)230-172(274)131(83-111-45-33-31-34-46-111)219-167(269)126(64-69-149(253)254)214-166(268)122(51-41-42-70-195-144(245)98-290-79-78-289-76-74-197-145(246)99-291-80-77-288-75-73-196-139(240)66-61-127(183(285)286)211-140(241)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-146(247)248)212-158(260)107(12)206-157(259)106(11)207-165(267)125(60-65-138(189)239)210-142(243)92-202-163(265)123(62-67-147(249)250)213-168(270)128(81-101(2)3)217-169(271)130(85-113-56-58-116(238)59-57-113)220-175(277)135(95-233)223-177(279)137(97-235)224-179(281)153(104(8)9)229-174(276)134(88-150(255)256)221-176(278)136(96-234)225-182(284)156(110(15)237)231-173(275)132(84-112-47-35-32-36-48-112)222-181(283)155(109(14)236)227-143(244)93-203-164(266)124(63-68-148(251)252)226-184(287)187(16,17)232-160(262)118(188)87-115-90-194-100-205-115/h31-36,39-40,45-50,56-59,89-90,100-110,118,120-137,152-156,200,233-238H,18-30,37-38,41-44,51-55,60-88,91-99,188H2,1-17H3,(H2,189,239)(H,194,205)(H,195,245)(H,196,240)(H,197,246)(H,201,264)(H,202,265)(H,203,266)(H,204,263)(H,206,259)(H,207,267)(H,208,282)(H,209,242)(H,210,243)(H,211,241)(H,212,260)(H,213,270)(H,214,268)(H,215,280)(H,216,261)(H,217,271)(H,218,272)(H,219,269)(H,220,277)(H,221,278)(H,222,283)(H,223,279)(H,224,281)(H,225,284)(H,226,287)(H,227,244)(H,228,273)(H,229,276)(H,230,274)(H,231,275)(H,232,262)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,190,191,198)(H4,192,193,199)/t105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127+,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1

Substance Classes

Synthesis Path




Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
Lorem Lorem oral once daily formulation
EU Lorem Lorem
Lorem Lorem oral once daily formulation
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,seddiamvoluptua.Atveroeosetaccusametjustoduodoloresetearebum.Stetclitakasd

References

    • a) Lau, J. et al., J. Med. Chem., (2015) 58, 7370-7380.
    • Chinese Journal of Pharmaceuticals, (2018) 49 (6), 742.
    • US 9 999 999 (Novo Nordisk; 6.3.2012; appl. 17.9.2008; EP-prior. 18.3.2005).
    • US 9 999 999 (Novo Nordisk; 17.9.2013; appl. 5.3.2012; EP-prior. 18.3.2005).
    • b) US 9999 9999999 (Novetide; 1.3.2018; appl. 22.9.2015; GR-prior. 23.9.2014).
    • CN 999 999 999 (Hangzhou Adlai Nortye Pharma; 18.2.2015; appl. 24.10.2014).
    • c) WO 9999 999999 (Shenzhen Jymed Technol.; 22.2.2018; appl. 20.5.2017; CN-prior. 19.8.2016).
  • Injection devices:

    • US 9 999 999 (Novo Nordisk; 1.4.2014; appl. 25.9.2012; EP-prior. 21.10.2004).
    • US 9 999 999 (Novo Nordisk; 15.9.2015; appl. 1.8.2010; EP-prior. 24.10.2008).
    • US 9 999 999 (Novo Nordisk; 8.11.2016; appl. 30.1.2014; DK-prior. 5.1.2001).
    • US 9 999 999 (Novo Nordisk; 3.10.2017; appl. 21.11.2014; EP-prior. 27.7.2005).
    • EP 9 999 999 (Novetide; 27.9.2017; appl. 22.9.2015; GR-prior. 23.9.2014).
  • Oral dosing and compositions:

    • Twarog, C. et al., Pharmaceutics, (2019) 11, 78.
    • WO 9999 999999 (Hoffmann-LaRoche/Emisphere; 13.3.2008; appl. 30.8.2007; USA-prior. 7.9.2006).
    • US 9 999 999 (Novo Nordisk; 8.3.2016; appl. 16.12.2011; USA-prior. 20.12.2010).
    • US 99 999 999 (Novo Nordisk; 2.10.2018; appl. 9.2.2016; USA-prior. 20.12.2010).
    • US 99 999 999 (Novo Nordisk; 2.11.2017; appl. 17.7.2017; EP-prior. 2.5.2013).
    • US 9 999 999 (Novo Nordisk; 12.6.2018; appl. 19.6.2013; EP-prior. 20.6.2012).