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Acebutolol
  • ATC: C07AB04; C07BB04
  • Use: Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:336.43 g/mol
  • CAS-RN:37517-30-9
  • InChI Key:GOEMGAFJFRBGGG-UHFFFAOYSA-N
  • InChI:InChI=1S/C18H28N2O4/c1-​5-​6-​18(23)​20-​14-​7-​8-​17(16(9-​14)​13(4)​21)​24-​11-​15(22)​10-​19-​12(2)​3/h7-​9,​12,​15,​19,​22H,​5-​6,​10-​11H2,​1-​4H3,​(H,​20,​23)
  • EINECS:253-539-0
  • LD50:75.2 mg/kg (M, i.v.);
    4 mg/kg (dog, i.v.)

Derivatives

    (R)-base

  • Use:
  • Formula: Lorem ipsum dolor sit amet,
  • MW:336.43 g/mol
  • CAS-RN:68107-81-3

    (S)-base

  • Use:
  • Formula: Lorem ipsum dolor sit amet,
  • MW:336.43 g/mol
  • CAS-RN:68107-82-4

    (RS)-monohydrochloride

  • Use:
  • Formula: Lorem ipsum dolor sit amet,
  • MW:372.89 g/mol
  • CAS-RN:34381-68-5
  • EINECS:251-980-3
  • LD50:185 mg/kg (M, i.p.); 53 mg/kg (M, i.v.); 4050 mg/kg (M, p.o.); 291 mg/kg (M, s.c.);
    222 mg/kg (R, i.p.); 103 mg/kg (R, i.v.); 6620 mg/kg (R, p.o.); 1310 mg/kg (R, s.c.);
    41 mg/kg (rabbit, i.v.); 296 mg/kg (rabbit, p.o.)

Substance Classes

Synthesis Path




Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
40188-45-2 C12H15NO3 2-acetyl-4-butyramidophenol Butanamide, N-(3-acetyl-4-hydroxyphenyl)-
40188-44-1 C12H15NO3 O-acetyl-4-butyramidophenol Butanamide, N-[4-(acetyloxy)phenyl]-
75-36-5 C2H3ClO acetyl chloride Acetyl chloride
123-30-8 C6H7NO 4-aminophenol Phenol, 4-amino-
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem ,1977
Lorem Lorem ,1982 comb.
Lorem Lorem comb.
F Lorem Lorem
GB Lorem Lorem ,1982 comb.
Lorem Lorem ,1975
I Lorem Lorem
Lorem Lorem
Lorem Lorem ,1981
Lorem Lorem ,1980
J Lorem Lorem Lorem
Lorem Lorem
USA Lorem Lorem ,1985
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreet

References

    • GB 9 999 999 (May & Baker; appl. 22.12.1967).
    • DAS 9 999 999 (May & Baker; appl. 19.12.1968; GB-prior. 22.12.1967, 14.5.1968, 2.8.1968).
    • US 9 999 999 (May & Baker; 10.4.1973; GB-prior. 22.12.1967, 14.5.1968, 2.8.1968).
    • US 9 999 999 (May & Baker; 31.12.1974; GB-prior. 22.12.1967, 14.5.1968, 2.8.1968).

  • preparation of 4-butyramidophenol:

    • Kuhn; Koehler; Koehler: Hoppe-Seyler's Z. Physiol. Chem. (HSZPAZ) 247, 197, 999 (1937).
    • Verma, K.K.; Tyagi, P.: Anal. Chem. (ANCHAM) 56 (12), 9999 (1984).
    • US 9 999 999 (Esso Research & Eng. Co.; 25.2.1958; appl. 13.1.1955).
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