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Abemaciclib
  • Synonyms: LY-2835219; Bemaciclib
  • ATC: L01EF03
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:506.6 g/mol
  • CAS-RN:1231929-97-7
  • InChI Key:UZWDCWONPYILKI-UHFFFAOYSA-N
  • InChI:InChI=1S/C27H32F2N8/c1-​5-​35-​8-​10-​36(11-​9-​35)​16-​19-​6-​7-​24(30-​14-​19)​33-​27-​31-​15-​22(29)​25(34-​27)​20-​12-​21(28)​26-​23(13-​20)​37(17(2)​3)​18(4)​32-​26/h6-​7,​12-​15,​17H,​5,​8-​11,​16H2,​1-​4H3,​(H,​30,​31,​33,​34)

Derivatives

    Mesylate

  • Formula: C27H32F2N8 • CH4O3S
  • MW:602.7 g/mol
  • CAS-RN:1231930-82-7

Substance Classes

Synthesis Path






Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
75-31-0 C3H9N 2-propanamine
75-36-5 C2H3ClO acetyl chloride
1118-69-0 C5H11NO N-isopropylacetamide
67567-26-4 C6H4BrF2N 4-bromo-2,6-difluoro-phenylamine
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
EU Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,sed

References

    • a WO 9999 999999 (E. Lilly; 1.7.2010; appl. 15.12.2009; EP-prior. 22.12.2008).
    • US 9 999 999 (E. Lilly; 21.12.2010; appl. 15.12.2009; EP-prior. 22.12.2008).
    • b Frederick, M. O. et al., Tetrahedron Lett., (2015) 56, 949-951.
    • c Frederick, M. O. et al., Org. Process Res. Dev., (2017) 21, 1447-1451.

  • Abemaciclib form iv:

    • WO 9999 99999 (Ratiopharm; 29.6.2017; appl. 20.12.2016; EP-prior. 22.12.2015).
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