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Acetylsalicylic acid

  • Synonyms: Acidum acetylsalicylicum, Aspirin, ASS
  • ATC: A01AD05; B01AC06; M01BA03; N02BA01; N02BA51
  • Use: Lorem  Lorem  Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:180.16 g/mol
  • CAS-RN:50-78-2
  • InChI Key:BSYNRYMUTXBXSQ-UHFFFAOYSA-N
  • InChI:InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
  • EINECS:200-064-1
  • LD50: 280 mg/kg (M, i.p.); 250 mg/kg (M, p.o.); 1520 mg/kg (M, s.c.);
    340 mg/kg (R, i.p.); 200 mg/kg (R, p.o.); 1600 mg/kg (R, s.c.);
    1075 mg/kg (g. p., p.o.);
    1010 mg/kg (rabbit, p.o.);
    681 mg/kg (dog, i.v.); 700 mg/kg (dog, p.o.)

Derivatives

    aluminum salt

  • Formula: C27H21AlO12
  • MW:564.44 g/mol
  • CAS-RN:147-31-9

    calcium salt

  • Formula: C18H14CaO8
  • MW:398.38 g/mol
  • CAS-RN:69-46-5
  • EINECS:200-707-6

    lithium salt

  • Formula: C9H7LiO4
  • MW:186.09 g/mol
  • CAS-RN:552-98-7
  • EINECS:209-029-5

    sodium salt

  • Formula: C9H7NaO4
  • MW:202.14 g/mol
  • CAS-RN:493-53-8
  • EINECS:207-777-7
  • LD50: 730 mg/kg (M, i.p.);
    1450 mg/kg (R, i.p.)

    magnesium salt

  • Formula: C18H14MgO8
  • MW:382.61 g/mol
  • CAS-RN:132-49-0
  • EINECS:205-062-4
  • LD50: 620 mg/kg (M, s.c.)

    lysine salt (1:1)

  • Formula: C9H8O4 • C6H14N2O2
  • MW:326.35 g/mol
  • CAS-RN:62952-06-1
  • LD50: 950 mg/kg (M, i.v.); 3270 mg/kg (M, p.o.);
    1525 mg/kg (R, i.v.); 4350 mg/kg (R, p.o.)

Substance Classes

Synthesis Path




Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
108-24-7 C4H6O3 acetic anhydride Acetic acid, anhydride
69-72-7 C7H6O3 salicylic acid Benzoic acid, 2-hydroxy-

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem ipsum Lorem
Lorem ipsum dolor Lorem
F Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
GB Lorem Lorem
Lorem Lorem
Lorem Lorem
I Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem as lysine salt
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
J Lorem Lorem Lorem
Lorem ipsum dolor sit amet,
USA Lorem Lorem
Lorem ipsum Lorem
Lorem Lorem
Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,seddiamvoluptua.Atveroeosetaccusametjustoduo

References

    • Ullmanns Encykl. Tech. Chem., 3. Aufl., Vol. 13, 90.
    • US 9 999 999 (Norwich Pharmacal; 15.2.1966; appl. 22.7.1964).
  • acetylation in presence of pyridine for avoidance of formation of acetylsalicylic anhydride and acetylsalicylsalicylic acid:

    • DOS 9 999 999 (A. L. de Week, H. Bundgaard; appl. 6.8.1976).
  • acetylation in presence of H2SO4:

    • US 9 999 999 (J. Kamlet; 1956; appl. 1954).
  • crystallization:

    • US 9 999 999 (Monsanto; 1959; appl. 1957).
  • aluminum salts:

    • DRP 999 999 (Chinoin; appl. 1931; H-prior. 1931).
    • US 9 999 999 (Reheis Comp.; 1954; appl. 1951).
    • US 9 999 999 (Keystone Chemurgic Corp.; 1959; appl. 1955).
    • GB 999 999 (Hardman & Holden; appl. 1959).
  • aluminum acetylsalicylate glutaminate:

    • DOS 9 999 999 (Kyowa Hakko; appl. 13.3.1979; J-prior. 13.3.1978).