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Aciclovir
  • Synonyms: Acyclovir, Acycloguanosine
  • ATC: D06BB03; J05AB01; S01AD03
  • Use: Lorem  Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:225.21 g/mol
  • CAS-RN:59277-89-3
  • InChI Key:MKUXAQIIEYXACX-UHFFFAOYSA-N
  • InChI:InChI=1S/C8H11N5O3/c9-​8-​11-​6-​5(7(15)​12-​8)​10-​3-​13(6)​4-​16-​2-​1-​14/h3,​14H,​1-​2,​4H2,​(H3,​9,​11,​12,​15)
  • EINECS:261-685-1
  • LD50:1000 mg/kg (M, i.p.); 1118 mg/kg (M, i.v.); >10000 mg/kg (M, p.o.); 1118 mg/kg (M, s.c.);
    860 mg/kg (R, i.p.); 910 mg/kg (R, i.v.); >20000 mg/kg (R, p.o.); 620 mg/kg (R, s.c.)

Derivatives

    monosodium salt

  • Use:
  • Formula: Lorem ipsum dolor sit amet,
  • MW:247.19 g/mol
  • CAS-RN:69657-51-8
  • LD50:999 mg/kg (M, i.p.); >10000 mg/kg (M, p.o.);
    1210 mg/kg (R, i.p.); >600 mg/kg (R, i.v.); >20000 mg/kg (R, p.o.); 650 mg/kg (R, s.c.)

Substance Classes

Synthesis Path

























Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
108-24-7 C4H6O3 acetic anhydride Acetic acid, anhydride
59278-00-1 C7H12O5 2-acetoxyethyl acetoxymethyl ether Ethanol, 2-[(acetyloxy)methoxy]-, acetate
133186-23-9 C17H17N5O5 N2-acetyl-9-(2-benzoyloxyethoxymethyl)guanine Acetamide, N-[9-[[2-(benzoyloxy)ethoxy]methyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-
19962-37-9 C7H7N5O2 N2-acetylguanine Acetamide, N-(6,7-dihydro-6-oxo-1H-purin-2-yl)-
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem ,1983
Lorem ipsum dolor
F Lorem Lorem
Lorem Lorem
Lorem ipsum Lorem
Lorem Lorem
GB Lorem Lorem
I Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem ,1984
J Lorem Lorem
USA Lorem Lorem ,1985
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,seddiamvoluptua.Atveroeosetaccusametjustoduodoloresetearebum.Stetclita

References

    • Schaeffer, H.J. et al.: Nature (London) (NATUAS) 272, 999 (1978).
    • DE 9 999 999 (Wellcome; appl. 2.9.1975; GB-prior. 2.9.1974).
    • US 9 999 999 (Wellcome; 22.4.1980; GB-prior. 2.9.1974).
    • GB 9 999 999 (Burroughs Wellcome; GB-prior. 2.9.1974).
    • c GB 9 999 999 (Wellcome; appl. 26.8.1977; USA-prior. 27.8.1976).
    •  Matsumoto, H. et al.: Chem. Pharm. Bull. (CPBTAL) 36, 9999 (1988).
    • f EP 999 999 (Roche; appl. 13.7.1995; USA-prior. 26.7.1994, 27.4.1995).

  • alternative synthesis from 4-aminoimidazole-5-carboxamide:

    • WO 9 999 999 (GEA Farm.; 4.10.1990; DK-prior. 20.3.1989).

  • alternative synthesis via formylguanine:

    • WO 9 999 999 (Recordati; appl. 3.2.1994; I-prior. 10.9.1993).

  • synthesis using 1,3-dioxolane:

    • US 9 999 999 (Syntex; appl. 27.4.1995; USA-prior. 27.7.1994).

  • improved procedures:

    • DE 99 999 999 (Boehringer Ingelheim; D-prior. 28.9.1995).
    • WO 9 999 999 (Mallinckrodt; appl. 17.12.1996; USA-prior. 28.12.1995).
    • DE 99 999 999 (B. Lehmann; 6.2.1996).
    • EP 999 999 (Lupin Lab.; EP-prior. 9.4.1996).
    • US 9 999 999 (Ajinomoto; appl. 18.3.1994; J-prior. 18.9.1991).
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