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Acrivastine
  • Synonyms: BW-825C
  • ATC: R06AX18
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:348.45 g/mol
  • CAS-RN:87848-99-5
  • InChI Key:PWACSDKDOHSSQD-IUTFFREVSA-N
  • InChI:InChI=1S/C22H24N2O2/c1-​17-​7-​9-​18(10-​8-​17)​20(13-​16-​24-​14-​2-​3-​15-​24)​21-​6-​4-​5-​19(23-​21)​11-​12-​22(25)​26/h4-​13H,​2-​3,​14-​16H2,​1H3,​(H,​25,​26)/b12-​11+,​20-​13+

Substance Classes

Synthesis Path













Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
3375-31-3 C4H6O4Pd acetic acid palladium(2+) salt Acetic acid, palladium(2+) salt
34199-87-6 C8H8BrNO2 2-bromo-6-(1,3-dioxolan-2-yl)pyridine Pyridine, 2-bromo-6-(1,3-dioxolan-2-yl)-
34160-40-2 C6H4BrNO 6-bromopyridine-2-carboxaldehyde 2-Pyridinecarboxaldehyde, 6-bromo-
87848-95-1 C13H10BrNO 2-bromo-6-(p-toluoyl)pyridine Methanone, (6-bromo-2-pyridinyl)(4-methylphenyl)-
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
GB Lorem Lorem
Lorem Lorem ,1988
I Lorem Lorem
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetur

References

    • EP 99 999 (Wellcome; appl. 3.2.1983; GB-prior. 4.2.1983).
    • US 9 999 999 (Burroughs Wellcome; 26.2.1985; GB-prior. 4.2.1982).
    • US 9 999 999 (Burroughs Wellcome; 31.12.1985; GB-prior. 4.2.1982).
    • US 9 999 999 (Burroughs Wellcome; 17.3.1987; GB-prior. 4.2.1982).
    • US 9 999 999 (Burroughs Wellcome; 14.4.1987; GB-prior. 4.2.1982).
    • EP 999 999 (Wellcome; appl. 3.2.1983; GB-prior. 4.2.1982, 18.10.1982).

  • preparation of 2,6-dibromopyridine:

    • Nakagawa, H. et al.: Chem. Pharm. Bull. (CPBTAL) 46 (10), 1656-1657 (1998).
    • Malinowski, M.; Kczmarek, L.: Synthesis (SYNTBF) 11 1013-1015 (1987).
    • den Hertog; Wibaut: Recl. Trav. Chim. Pays-Bas (RTCPA3) 51 940, 999 (1932).
    • McElvain; Goese: J. Am. Chem. Soc. (JACSAT) 65 2227, 9999 (1943).

  • preparation of 2-bromo-6-(1,3-dioxolan-2-yl)pyridine:

    • Davies, S.R. et al.: J. Organomet. Chem. (JORCAI) 550 (1-2), 99 (1998).
    • Niemitz, J.: Synth. Commun. (SYNCAV) 11 (4), 999 (1981).
    • Heirtzler, F.R.; Neuberger, N.; Zehnder, Margareta; Constable, E.G.: Liebigs Ann./Recl. (LIARFV) (2), 297-302 (1997).

  • preparation of 6-bromopyridine-6-carboxaldehyde:

    • Meth-Cohn, O.; Jiang, H.: J. Chem. Soc., Perkin Trans. 9 (JCPRB4) 22, 9999 (1998).
    • Uenishi, J.; Nishiwaki, K.; Hata, S.; Nakamura, K.: Tetrahedron Lett. (TELEAY) 35 (43), 9999 (1994).
    • Ashimori, A. et al.: Chem. Pharm. Bull. (CPBTAL) 38 (9), 9999 (1990).

  • preparation of 1-pyrrolidino-3-(4-tolyl)-3-propanone via Mannich-condensation from p-methylacetophenone:

    • Adamson et al.: J. Chem. Soc. (JCSOA9) 312, 999 (1958).
    • Huang, Y.; Hall, I: Pharmazie (PHARAT) 51 (4), 199-206 (1996).
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