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Adefovir dipivoxil
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Synonyms:
PMEA, GS-393-dipivoxil
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ATC:
J05AF08
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Use:
Lorem
Lorem
Lorem
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Chemical name:
Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
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Formula:
Lorem ipsum dolor sit amet,
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MW:501.48 g/mol
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CAS-RN:142340-99-6
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InChI Key:WOZSCQDILHKSGG-UHFFFAOYSA-N
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InChI:InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
Substances Referenced in Synthesis Path
CAS-RN |
Formula |
Chemical Name |
CAS Index Name |
73-24-5 |
C5H5N5 |
adenine |
1H-Purin-6-amine |
18997-19-8 |
C6H11ClO2 |
chloromethyl 2,2-dimethylpropanoate |
Propanoic acid, 2,2-dimethyl-, chloromethyl ester |
18997-19-8 |
C6H11ClO2 |
chloromethyl pivalate |
Propanoic acid, 2,2-dimethyl-, chloromethyl ester |
116384-53-3 |
C12H20N5O4P |
9-[2-(diethylphosphonomethoxy)ethyl]adenine |
Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-, diethyl ester |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Trade Names
Country |
Trade Name |
Vendor |
Annotation |
D |
Lorem |
Lorem
,2003 |
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F |
Lorem |
Lorem
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GB |
Lorem |
Lorem
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I |
Lorem |
Lorem
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J |
Lorem |
Lorem
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USA |
Lorem |
Lorem
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(wfm = withdrawn from market)
References
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- a Holy, A. et al.: Collect. Czech. Chem. Commun. (CCCCAK) 52, 9999 (1987).
- S 9999999 (Inst. Org. Chem. Acad. Sci. of Czech Republic and Rega Stichting; 2.9.1997; appl. 11.10.1994; USA-prior. 14.9.1990, 16.11.1993).
- EP 999 999 (Inst. Org. Chem. Acad. Sci. of Czech Republic and Rega Stichting; appl. 10.9.1991; USA-prior. 14.9.1990).
- Starrett, J.E et al.: J. Med. Chem. (JMCMAR) 37, 9999 (1994).
- a, b Yu, R.H. et al.: Org. Process Res. Dev. (OPRDFK) 3, 53-55 (1999).
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preparation of crystalline forms:
- US 9 999 999 (Gilead Sciences; 17.9.2002; appl. 10.9.2001; USA-prior. 25.7.1997, 23.7.1998).
- EP 9 999 999 (Gilead Sciences; appl. 23.7.1998; USA-prior. 25.7.1997).
- WO 9 999 999 (Gilead Sciences; 24.2.1999; appl. 23.7.1998; USA-prior. 25.7.1997).
- US 9 999 999 999 (Gilead Sciences; 18.4.2002; appl. 10.9.2001; USA-prior. 23.7.1998).
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preparation of 9-[2-(phosphonomethoxy)ethyl]adenine IV ("PMEA"):
- US 9 999 999 (Ceskoslovenska akademie ved.; 28.2.1989; appl. 25.4.1986; CS-prior. 25.4.1985).
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preparation of diethyl p-toluene sulfonyloxymethylphosphonate II:
- see tenofovir disoproxil fumerate.
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pharmaceutical formulations:
- WO 9 999 999 999 (Gilead Sciences; 22.6.2000; appl. 14.12.1999; USA-prior. 15.12.1998).