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Adefovir dipivoxil
  • Synonyms: PMEA, GS-393-dipivoxil
  • ATC: J05AF08
  • Use: Lorem  Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:501.48 g/mol
  • CAS-RN:142340-99-6
  • InChI Key:WOZSCQDILHKSGG-UHFFFAOYSA-N
  • InChI:InChI=1S/C20H32N5O8P/c1-​19(2,​3)​17(26)​30-​11-​32-​34(28,​33-​12-​31-​18(27)​20(4,​5)​6)​13-​29-​8-​7-​25-​10-​24-​14-​15(21)​22-​9-​23-​16(14)​25/h9-​10H,​7-​8,​11-​13H2,​1-​6H3,​(H2,​21,​22,​23)

Substance Classes

Synthesis Path




Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
73-24-5 C5H5N5 adenine 1H-Purin-6-amine
18997-19-8 C6H11ClO2 chloromethyl 2,2-dimethylpropanoate Propanoic acid, 2,2-dimethyl-, chloromethyl ester
18997-19-8 C6H11ClO2 chloromethyl pivalate Propanoic acid, 2,2-dimethyl-, chloromethyl ester
116384-53-3 C12H20N5O4P 9-[2-(diethylphosphonomethoxy)ethyl]adenine Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-, diethyl ester
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem ,2003
F Lorem Lorem
GB Lorem Lorem
I Lorem Lorem
J Lorem Lorem
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolor

References

    • a Holy, A. et al.: Collect. Czech. Chem. Commun. (CCCCAK) 52, 9999 (1987).
    •  S 9999999 (Inst. Org. Chem. Acad. Sci. of Czech Republic and Rega Stichting; 2.9.1997; appl. 11.10.1994; USA-prior. 14.9.1990, 16.11.1993).
    •  EP 999 999 (Inst. Org. Chem. Acad. Sci. of Czech Republic and Rega Stichting; appl. 10.9.1991; USA-prior. 14.9.1990).
    •  Starrett, J.E et al.: J. Med. Chem. (JMCMAR) 37, 9999 (1994).
    • a, b Yu, R.H. et al.: Org. Process Res. Dev. (OPRDFK) 3, 53-55 (1999).

  • preparation of crystalline forms:

    • US 9 999 999 (Gilead Sciences; 17.9.2002; appl. 10.9.2001; USA-prior. 25.7.1997, 23.7.1998).
    • EP 9 999 999 (Gilead Sciences; appl. 23.7.1998; USA-prior. 25.7.1997).
    • WO 9 999 999 (Gilead Sciences; 24.2.1999; appl. 23.7.1998; USA-prior. 25.7.1997).
    • US 9 999 999 999 (Gilead Sciences; 18.4.2002; appl. 10.9.2001; USA-prior. 23.7.1998).

  • preparation of 9-[2-(phosphonomethoxy)ethyl]adenine IV ("PMEA"):

    • US 9 999 999 (Ceskoslovenska akademie ved.; 28.2.1989; appl. 25.4.1986; CS-prior. 25.4.1985).

  • preparation of diethyl p-toluene sulfonyloxymethylphosphonate II:

    • see tenofovir disoproxil fumerate.

  • pharmaceutical formulations:

    • WO 9 999 999 999 (Gilead Sciences; 22.6.2000; appl. 14.12.1999; USA-prior. 15.12.1998).
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