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Afatinib

  • Synonyms: BIBW 2992
  • ATC: L01EB03
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:485.9 g/mol
  • CAS-RN:439081-18-2; 850140-72-6
  • InChI Key:ULXXDDBFHOBEHA-CWDCEQMOSA-N
  • InChI:InChI=1S/C24H25ClFN5O3/c1-​31(2)​8-​3-​4-​23(32)​30-​21-​11-​17-​20(12-​22(21)​34-​16-​7-​9-​33-​13-​16)​27-​14-​28-​24(17)​29-​15-​5-​6-​19(26)​18(25)​10-​15/h3-​6,​10-​12,​14,​16H,​7-​9,​13H2,​1-​2H3,​(H,​30,​32)​(H,​27,​28,​29)/b4-​3+/t16-​/m0/s1

Derivatives

    dimaleate

  • Use:
  • Formula: Lorem ipsum dolor sit amet,
  • MW:718.1 g/mol
  • CAS-RN:850140-73-7

Substance Classes

Synthesis Path







Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
446-32-2 C7H6FNO2 4-fluoro-anthranilic acid -
162012-70-6 C8H3ClFN3O2 4-chloro-7-fluoro-6-nitroquinazoline -
367-21-5 C6H5ClFN 3-chloro-4-fluoroaniline -
86087-23-2 C4H8O2 (S)-(+)-3-hydroxytetrahydrofuran -
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
EU Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetur

References

    • a US 9 999 999 (American Cyanamid; 26.6.2001; appl. 29.7.1998; USA-prior. 1.8.1997).
    • WO 9 999 999 (Boehringer Ingelheim; 27.6.2002; appl. 12.12.2001; DE-prior. 20.12.2000).
    • US RE 99999 (Boehringer Ingelheim; 29.5.2012; appl. 18.8.2009; DE-prior. 20.12.2000).
    • b US 9 999 999 (Boehringer Ingelheim; 1.2.2007; appl. 14.7.2006; DE-prior. 17.10.2003).
  • crystalline forms of Afatinib di-maleate:

    • WO 9999 999999 (Ratiopharm/Teva; 11.4.2013; appl. 25.4.2012; USA-prior. 6.10.2011).
    • Solca, F. et al., J. Pharmacol. Exp. Ther., (2012) 343(2), 342-350.
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