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Afatinib
  • Synonyms: BIBW 2992
  • ATC: L01EB03
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:485.9 g/mol
  • CAS-RN:439081-18-2; 850140-72-6
  • InChI Key:ULXXDDBFHOBEHA-CWDCEQMOSA-N
  • InChI:InChI=1S/C24H25ClFN5O3/c1-​31(2)​8-​3-​4-​23(32)​30-​21-​11-​17-​20(12-​22(21)​34-​16-​7-​9-​33-​13-​16)​27-​14-​28-​24(17)​29-​15-​5-​6-​19(26)​18(25)​10-​15/h3-​6,​10-​12,​14,​16H,​7-​9,​13H2,​1-​2H3,​(H,​30,​32)​(H,​27,​28,​29)/b4-​3+/t16-​/m0/s1

Derivatives

    dimaleate

  • Formula: C32H33ClFN5O11
  • MW:718.1 g/mol
  • CAS-RN:850140-73-7

Substance Classes

Synthesis Path



Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
446-32-2 C7H6FNO2 4-fluoro-anthranilic acid
162012-70-6 C8H3ClFN3O2 4-chloro-7-fluoro-6-nitroquinazoline
367-21-5 C6H5ClFN 3-chloro-4-fluoroaniline
86087-23-2 C4H8O2 (S)-(+)-3-hydroxytetrahydrofuran
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
EU Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetur

References

    • a US 9 999 999 (American Cyanamid; 26.6.2001; appl. 29.7.1998; USA-prior. 1.8.1997).
    • WO 9 999 999 (Boehringer Ingelheim; 27.6.2002; appl. 12.12.2001; DE-prior. 20.12.2000).
    • US RE 99999 (Boehringer Ingelheim; 29.5.2012; appl. 18.8.2009; DE-prior. 20.12.2000).
    • b US 9 999 999 (Boehringer Ingelheim; 1.2.2007; appl. 14.7.2006; DE-prior. 17.10.2003).

  • crystalline forms of Afatinib di-maleate:

    • WO 9999 999999 (Ratiopharm/Teva; 11.4.2013; appl. 25.4.2012; USA-prior. 6.10.2011).
    • Solca, F. et al., J. Pharmacol. Exp. Ther., (2012) 343(2), 342-350.
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