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Afamelanotide

  • Synonyms: Melanotan; NDP-MSH; EPT1647; CUV1647
  • ATC: D02BB02
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:1646.8 g/mol
  • CAS-RN:75921-69-6
  • InChI Key:UAHFGYDRQSXQEB-LEBBXHLNSA-N
  • InChI:InChI=1S/C78H111N21O19/c1-​5-​6-​19-​52(91-​75(116)​61(41-​101)​97-​72(113)​57(34-​46-​24-​26-​49(103)​27-​25-​46)​94-​74(115)​60(40-​100)​88-​44(4)​102)​68(109)​92-​54(28-​29-​64(105)​106)​70(111)​96-​59(36-​48-​38-​83-​42-​87-​48)​73(114)​93-​56(33-​45-​16-​8-​7-​9-​17-​45)​71(112)​90-​53(22-​14-​31-​84-​78(81)​82)​69(110)​95-​58(35-​47-​37-​85-​51-​20-​11-​10-​18-​50(47)​51)​67(108)​86-​39-​63(104)​89-​55(21-​12-​13-​30-​79)​77(118)​99-​32-​15-​23-​62(99)​76(117)​98-​65(43(2)​3)​66(80)​107/h7-​11,​16-​18,​20,​24-​27,​37-​38,​42-​43,​52-​62,​65,​85,​100-​101,​103H,​5-​6,​12-​15,​19,​21-​23,​28-​36,​39-​41,​79H2,​1-​4H3,​(H2,​80,​107)​(H,​83,​87)​(H,​86,​108)​(H,​88,​102)​(H,​89,​104)​(H,​90,​112)​(H,​91,​116)​(H,​92,​109)​(H,​93,​114)​(H,​94,​115)​(H,​95,​110)​(H,​96,​111)​(H,​97,​113)​(H,​98,​117)​(H,​105,​106)​(H4,​81,​82,​84)/t52-,​53-,​54-,​55-,​56+,​57-,​58-,​59-,​60-,​61-,​62-,​65-​/m0/s1

Substance Classes

Synthesis Path

  • Afamelanotide is synthesized by solution phase peptide chemistry using commercially available starting materials.



Trade Names

Country Trade Name Vendor Annotation
EU Lorem Lorem
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiam

References

    • Langendonk, J. G. et al., N. Engl. J. Med., (2015) 373, 48-59.
    • US 9 999 999 (University of Arizona; 27.11.1984; appl. 11.6.1982).
  • α-MSH-derivatives for treatment of photodermatoses:

    • EP 9 999 999 (Clinuvel; 29.4.2015; appl. 31.8.2007; AU-prior. 31.8.2006).
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