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Adagrasib
  • Synonyms: MRTX849
  • ATC: L01XX77
  • Use: Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:604.13 g/mol
  • CAS-RN:2326521-71-3
  • InChI Key:PEMUGDMSUDYLHU-ZEQRLZLVSA-N
  • InChI:InChI=1S/C32H35ClFN7O2/c1-​21(34)​31(42)​41-​17-​16-​40(18-​23(41)​11-​13-​35)​30-​25-​12-​15-​39(28-​10-​4-​7-​22-​6-​3-​9-​26(33)​29(22)​28)​19-​27(25)​36-​32(37-​30)​43-​20-​24-​8-​5-​14-​38(24)​2/h3-​4,​6-​7,​9-​10,​23-​24H,​1,​5,​8,​11-​12,​14-​20H2,​2H3/t23-,​24-​/m0/s1

Substance Classes

Synthesis Path








Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
39514-19-7 C15H19NO3 ethyl 1-benzyl-3-oxopiperidine-4-carboxylate
1059735-34-0 C14H13Cl2N3 7-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine
34381-71-0 C6H13NO (S)-(1-methylpyrrolidin-2-yl)methanol
1589082-26-7 C6H11N3 (S)-2-(piperazin-2-yl)acetonitrile
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolor

References

    • a) Fell, J. B. et al., J. Med. Chem., (2020) 63, 6679-6693.
    • Fell, J. B. et al., ACS Med. Chem. Lett., (2018) 9, 1230-1234.
    • WO 9999 999 999 (Mirati Therapeutics; 23.11.2017; appl. 17.5.2017; USA-prior. 18.5.2016).
    • WO 9999 999 999 (Mirati Therapeutics/Array Biopharma; 23.5.2019; appl. 14.11.2018; USA-prior. 18.11.2017).
    • b) WO 9999 999 999 (Mirati Therapeutics; appl. 17.3.2022; appl. 10.9.2021; USA-prior. 11.9.2020).
    • c) Chen, C.-y. et al., Org. Lett., (2023) 25, 944-949.

  • Crystalline forms:

    • CN 999 999 999 (Du Chuang Shanghai Pharmaceutical; 22.10.2021; appl. 25.8.2021).
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