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Fluorouracil

  • Synonyms: Fluracilum
  • ATC: L01BC02
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:130.08 g/mol
  • CAS-RN:51-21-8
  • InChI Key:GHASVSINZRGABV-UHFFFAOYSA-N
  • InChI:InChI=1S/C4H3FN2O2/c5-​2-​1-​6-​4(9)​7-​3(2)​8/h1H,​(H2,​6,​7,​8,​9)
  • EINECS:200-085-6
  • LD50:81 mg/kg (M, i.v.); 115 mg/kg (M, p.o.);
    245 mg/kg (R, i.v.); 230 mg/kg (R, p.o.);
    30 mg/kg (dog, p.o.)

Substance Classes

Synthesis Path








Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
459-72-3 C4H7FO2 ethyl fluoroacetate Acetic acid, fluoro-, ethyl ester
109-94-4 C3H6O2 ethyl formate Formic acid, ethyl ester
185692-96-0 C5H7FO3 2-fluoro-3-hydroxy-2-propenoic acid ethyl ester 2-Propenoic acid, 2-fluoro-3-hydroxy-, ethyl ester
1480-92-8 C5H5FN2OS 5-fluoro-2-methylthiouracil 4(1H)-Pyrimidinone, 5-fluoro-2-(methylthio)-
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem
Lorem Lorem
Lorem ipsum Lorem
Lorem ipsum Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
Lorem Lorem
F Lorem Lorem
Lorem ipsum Lorem
GB Lorem Lorem
I Lorem Lorem
J Lorem Lorem
USA Lorem ipsum Lorem
Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,seddiamvoluptua.Atveroeosetaccusametjustoduodoloresetearebum.Stetclitakasdgubergren,

References

    • a US 9 999 999 (C. Heidelberger, R. Duschinsky; 6.8.1957; prior. 26.9.1956).
    •  Duschinsky, R. et al.: J. Am. Chem. Soc. (JACSAT) 79, 9999 (1957).
    • b Barton, D.H.R. et al.: J. Org. Chem. (JOCEAH) 37, 999 (1972).
    •  US 9 999 999 (I. L. Knuniants et al.; 8.8.1972; appl. 25.3.1970).
    •  US 9 999 999 (S. A. Giller et al.; 5.11.1974; appl. 22.9.1971).
    •  US 9 999 999 (PCR, Inc.; 4.5.1976; prior. 7.8.1967, 1.3.1968, 27.5.1970, 4.10.1971).
    •  DOS 9 999 999 (Research Inst. f. Med. and Chem.; appl. 4.10.1971; USA-prior. 5.10.1970).
    •  DOS 9 999 999 (Daikin Kogyo; appl. 29.4.1977; J-prior. 29.4.1976).
    •  DOS 9 999 999 (Daikin Kogyo; appl. 10.6.1977; J-prior. 11.6.1976).
  • synthesis from orotic acid by fluorination and following decarboxylation:

    • DOS 9 999 999 (Asahi Glass; appl. 16.6.1978; J-prior. 17.6.1977).
    • The Merck Index, 14th Ed., 999 (4181) (Rahway 2006).
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