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Olanzapine

  • Synonyms: LY-170053
  • ATC: N05AH03
  • Use: Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:312.44 g/mol
  • CAS-RN:132539-06-1
  • InChI Key:KVWDHTXUZHCGIO-UHFFFAOYSA-N
  • InChI:InChI=1S/C17H20N4S/c1-​12-​11-​13-​16(21-​9-​7-​20(2)​8-​10-​21)​18-​14-​5-​3-​4-​6-​15(14)​19-​17(13)​22-​12/h3-​6,​11,​19H,​7-​10H2,​1-​2H3

Substance Classes

Synthesis Path






Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
138564-58-6 C6H6N2S 2-amino-3-cyano-5-methylthiophene 3-Thiophenecarbonitrile, 2-amino-5-methyl-
C12H11N3S 4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine
88-73-3 C6H4ClNO2 o-chloronitrobenzene Benzene, 1-chloro-2-nitro-
109-77-3 C3H2N2 malononitrile Propanedinitrile
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
D Lorem Lorem
Lorem ipsum
F Lorem Lorem
GB Lorem Lorem
I Lorem Lorem
J Lorem Lorem
USA Lorem Lorem
Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdolore

References

    • US 9 999 999 (Lilly; 20.7.1993; appl. 23.4.1991, 22.5.1992; GB-prior. 25.4.1990).
    • EP 999 999 (Lilly; 13.9.1995; appl. 24.4.1991; GB-prior. 25.4.1990).
  • medical use:

    • US 9 999 999 (Lilly; 25.2.1997; appl. 23.4.1991, 22.5.1992, 8.4.1993, 13.2.1995).
    • Chakrabati, J.K. et al.: J. Med. Chem. (JMCMAR) 23, 878, 999 (1980).
    • Hagopian, G.S.; Meyers, D.B.; Markham, J.K.: Teratology (TJADAB) 35(2), Abst. P65 (1987).
    • Cen, J.: Chin. J. Pharm. Ind. (ZYGZEA) 32, 999 (2001).
  • olanzapine monohydrate and dihydrate preparation:

    • WO 999 999 999 (Dr. Reddy's; appl. 7.3.2001; IN-prior. 31.8.2000).
    • EP 999 999 (Lilly; 24.7.2002; appl. 22.9.1997; USA-prior. 23.9.1996).
    • US 9 999 999 (Lilly; 1.2.2000; appl. 23.9.1997; prior. 23.9.1996).
    • US 9 999 999 (Lilly; 26.6.2001; appl. 23.9.1997; prior. 23.9.1996).
  • solvates and polymorphs:

    • EP 999 999 (Lilly; 22.11.2000; appl. 22.3.1996; USA-prior. 24.3.1995).
    • EP 999 999 (Lilly; 21.11.2001; appl. 22.9.1997; USA-prior. 23.9.1996).
    • US 9 999 999 (Lilly; 20.5.1997; appl. 24.3.1995).
    • US 9 999 999 (U&I-Pharm.; 19.2.2002; appl. 31.3.2000; IN-prior. 28.12.1999).
    • EP 9 999 999 (Lilly; 8.10.2003; appl. 22.3.1996; USA-prior. 24.3.1995).
  • treatment of cerebral trauma or ischaemia:

    • EP 9 999 999 (Lilly; 3.3.2004; appl. 9.4.1998; USA-prior. 15.4.1997).
    • EP 999 999 (Lilly; 13.6.2001; appl. 9.4.1998; USA-prior. 15.4.1997).
  • solid oral formulation:

    • EP 999 999 (Lilly; 17.10.2001; appl. 22.3.1996; USA-prior. 24.3.1995).
    • EP 9 999 999 (Lilly; 15.12.2004; appl. 22.3.1996; USA-prior. 24.3.1995).
    • US 9 999 999 (Eli Lilly; 6.7.1999; appl. 20.9.1996; USA-prior. 24.3.1995).
  • new solvates of olanzapine pamoate suitable for i.m. injections:

    • WO 999 999 999 (Lilly; appl. 24.3.1999; USA-prior. 30.9.1998).
    • WO 9 999 999 (Lilly; appl. 30.9.1998; USA-prior. 30.9.1997).
  • crystalline olanzapine ("form II"):

    • EP 999 999 (Eli Lilly; 16.8.2001; appl. 22.3.1996; USA-prior. 24.3.1995).
  • crystalline olanzapine ("form I"):

    • US 9 999 999 (Sun Pharmac. Ind.; 14.6.2005; appl. 23.12.2002; IN-prior. 24.12.2001).
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