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Olanzapine
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Synonyms:
LY-170053
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ATC:
N05AH03
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Use:
Lorem
Lorem
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Chemical name:
Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
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Formula:
Lorem ipsum dolor sit amet,
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MW:312.44 g/mol
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CAS-RN:132539-06-1
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InChI Key:KVWDHTXUZHCGIO-UHFFFAOYSA-N
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InChI:InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
Synthesis Path
Substances Referenced in Synthesis Path
CAS-RN |
Formula |
Chemical Name |
CAS Index Name |
138564-58-6 |
C6H6N2S |
2-amino-3-cyano-5-methylthiophene |
3-Thiophenecarbonitrile, 2-amino-5-methyl- |
|
C12H11N3S |
4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine |
|
88-73-3 |
C6H4ClNO2 |
o-chloronitrobenzene |
Benzene, 1-chloro-2-nitro- |
109-77-3 |
C3H2N2 |
malononitrile |
Propanedinitrile |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Lorem |
Trade Names
Country |
Trade Name |
Vendor |
Annotation |
D |
Lorem |
Lorem
|
|
Lorem ipsum |
|
|
F |
Lorem |
Lorem
|
|
GB |
Lorem |
Lorem
|
|
I |
Lorem |
Lorem
|
|
J |
Lorem |
Lorem
|
|
USA |
Lorem |
Lorem
|
|
Lorem |
Lorem
|
|
(wfm = withdrawn from market)
Formulations
- Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdolore
References
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- US 9 999 999 (Lilly; 20.7.1993; appl. 23.4.1991, 22.5.1992; GB-prior. 25.4.1990).
- EP 999 999 (Lilly; 13.9.1995; appl. 24.4.1991; GB-prior. 25.4.1990).
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medical use:
- US 9 999 999 (Lilly; 25.2.1997; appl. 23.4.1991, 22.5.1992, 8.4.1993, 13.2.1995).
- Chakrabati, J.K. et al.: J. Med. Chem. (JMCMAR) 23, 878, 999 (1980).
- Hagopian, G.S.; Meyers, D.B.; Markham, J.K.: Teratology (TJADAB) 35(2), Abst. P65 (1987).
- Cen, J.: Chin. J. Pharm. Ind. (ZYGZEA) 32, 999 (2001).
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olanzapine monohydrate and dihydrate preparation:
- WO 999 999 999 (Dr. Reddy's; appl. 7.3.2001; IN-prior. 31.8.2000).
- EP 999 999 (Lilly; 24.7.2002; appl. 22.9.1997; USA-prior. 23.9.1996).
- US 9 999 999 (Lilly; 1.2.2000; appl. 23.9.1997; prior. 23.9.1996).
- US 9 999 999 (Lilly; 26.6.2001; appl. 23.9.1997; prior. 23.9.1996).
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solvates and polymorphs:
- EP 999 999 (Lilly; 22.11.2000; appl. 22.3.1996; USA-prior. 24.3.1995).
- EP 999 999 (Lilly; 21.11.2001; appl. 22.9.1997; USA-prior. 23.9.1996).
- US 9 999 999 (Lilly; 20.5.1997; appl. 24.3.1995).
- US 9 999 999 (U&I-Pharm.; 19.2.2002; appl. 31.3.2000; IN-prior. 28.12.1999).
- EP 9 999 999 (Lilly; 8.10.2003; appl. 22.3.1996; USA-prior. 24.3.1995).
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treatment of cerebral trauma or ischaemia:
- EP 9 999 999 (Lilly; 3.3.2004; appl. 9.4.1998; USA-prior. 15.4.1997).
- EP 999 999 (Lilly; 13.6.2001; appl. 9.4.1998; USA-prior. 15.4.1997).
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solid oral formulation:
- EP 999 999 (Lilly; 17.10.2001; appl. 22.3.1996; USA-prior. 24.3.1995).
- EP 9 999 999 (Lilly; 15.12.2004; appl. 22.3.1996; USA-prior. 24.3.1995).
- US 9 999 999 (Eli Lilly; 6.7.1999; appl. 20.9.1996; USA-prior. 24.3.1995).
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new solvates of olanzapine pamoate suitable for i.m. injections:
- WO 999 999 999 (Lilly; appl. 24.3.1999; USA-prior. 30.9.1998).
- WO 9 999 999 (Lilly; appl. 30.9.1998; USA-prior. 30.9.1997).
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crystalline olanzapine ("form II"):
- EP 999 999 (Eli Lilly; 16.8.2001; appl. 22.3.1996; USA-prior. 24.3.1995).
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crystalline olanzapine ("form I"):
- US 9 999 999 (Sun Pharmac. Ind.; 14.6.2005; appl. 23.12.2002; IN-prior. 24.12.2001).