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Escin

  • Synonyms: Aescin
  • ATC: C05CX01
  • Use: Lorem  Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:1131.27 g/mol
  • CAS-RN:6805-41-0
  • InChI Key:AXNVHPCVMSNXNP-MDSJTXJMSA-N
  • InChI:InChI:InChI=1S/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/t26?,27-,28-,29?,30?,31-,32+,33-,34-,35+,36+,37-,38-,39+,40+,41-,42+,43+,44+,47+,48+,49-,51+,52-,53-,54-,55+/m1/s1
  • EINECS:229-880-6
  • LD50: 6.7 mg/kg (M, i.p.); 2 mg/kg (M, i.v.); 165 mg/kg (M, p.o.); 38.59 mg/kg (M, s.c.);
    10.15 mg/kg (R, i.p.); 1600 mg/kg (R, i.v.); 833 mg/kg (R, p.o.); 150 mg/kg (R, s.c.)

Derivatives

    sodium salt

  • Formula: unspecified
  • MW:unspecified
  • CAS-RN:20977-05-3
  • EINECS:244-133-4
  • LD50: 8299 μg/kg (M, i.p.); 4730 mg/kg (M, i.v.); 134 mg/kg (M, p.o.); 92.53 mg/kg (M, s.c.);
    9180 μg/kg (R, i.p.); 8131 μg/kg (R, i.v.); 400 mg/kg (R, p.o.); 131 mg/kg (R, s.c.);
    9130 μg/kg (g. p., i.v.);
    5 mg/kg (rabbit, i.v.)

    β-Escin

  • Formula: C55H86O24
  • MW:1131.27 g/mol
  • CAS-RN:11072-93-8

Substance Classes

Enzymes

Synthesis Path




Trade Names

Country Trade Name Vendor Annotation
D Lorem ipsum dolor Lorem
Lorem Lorem
Lorem Lorem
F Lorem Lorem wfm
Lorem Lorem wfm
Lorem ipsum dolor
I Lorem Lorem comb. wfm
Lorem Lorem comb. wfm
Lorem Lorem comb. wfm
Lorem Lorem comb. wfm
Lorem Lorem comb. wfm
Lorem Lorem comb. wfm
Lorem Lorem comb. wfm
Lorem Lorem comb. wfm
Lorem Lorem comb. wfm
Lorem Lorem comb. wfm
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsitamet,consetetursadipscingelitr,seddiamnonumyeirmodtemporinviduntutlaboreetdoloremagnaaliquyamerat,seddiamvoluptua.At

References

  • extraction and purification:

    • DE 999 999 (Riedel-de Haen; appl. 1952).
    • DE 999 999 (Klinge; appl. 1951).
    • DAS 9 999 999 (VEB Arzneimittelwerk Dresden; appl. 1955).
    • DAS 9 999 999 (Dr. W. Schwabe; appl. 1953).
    • GB 999 999 (Klinge; appl. 1956).
    • GB 999 999 (Klinge; appl. 1956).
    • DE 9 999 999 (Klinge; appl. 1953).
    • DAS 9 999 999 (Madaus; appl. 11.3.1959).
    • US 9 999 999 (Klinge; 29.12.1964; D-prior. 14.6.1960).
    • DAS 9 999 999 (Chem. Fabrik Tempelhof; appl. 29.1.1962).
    • US 9 999 999 (Madaus; 1.3.1966; prior. 31.1.1961, 23.10.1963).
    • DOS 9 999 999 (J. Klosa; appl. 13.4.1967).
    • DOS 9 999 999 (Knoll; appl. 11.8.1967).
    • DAS 9 999 999 (Klinge; appl. 31.8.1967).
    • DE 9 999 999 (Knoll; appl. 20.1.1968).
    • DOS 9 999 999 (Nattermann; appl. 20.1.1969; A-prior. 31.5.1968).
    • DOS 9 999 999 (Klinge; appl. 6.8.1973).
    • DAS 9 999 999 (LEK; appl. 22.7.1977; YU-prior. 12.8.1976).
  • "water soluble" (X-ray amorphous) escin:

    • DE 9 999 999 (Madaus; appl. 14.12.1962).
    • DOS 9 999 999 (Nattermann; appl. 20.1.1969).
    • DOS 9 999 999 (LEK; appl. 24.11.1972; YU-prior. 6.12.1971).
    • GB 9 999 999 (Madaus; appl. 7.7.1976; D-prior. 11.7.1975).
  • separation of α- and β-escin:

    • DAS 9 999 999 (Klinge; appl. 14.6.1960).
    • US 9 999 999 (Klinge; 12.11.1963; D-prior. 14.6.1960).
  • conversion of β- into α-escin:

    • US 9 999 999 (Klinge; 17.6.1969; appl. 7.6.1967).
  • pharmacology:

    • Sirtori, C. R., Pharmacological Research, (2001) 44(3), 183-193.